Lnc-uc.147 Is Associated with Disease Stage of Liver, Gastric, and Renal Cancer

Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study aimed to investigate lnc-uc.147 in different types of cancer...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-01, Vol.13 (2), p.265
Main Authors: Rodrigues, Ana Carolina, Zambalde, Erika Pereira, Bellan, Daniel de Lima, Trindade, Edvaldo da Silva, Ribeiro, Enilze Maria de Souza Fonseca, Calin, George, Gradia, Daniela Fiori, Carvalho de Oliveira, Jaqueline
Format: Article
Language:English
Subjects:
Adenocarcinoma
Analysis
Apoptosis
Breast cancer
Breast Neoplasms - genetics
Carcinoma, Hepatocellular - genetics
Carcinoma, Renal Cell - genetics
Care and treatment
Cell cycle
Cell growth
Communication
Conserved Sequence - genetics
Diagnosis
Epidemiology
Experiments
Female
Flow cytometry
Gastric cancer
Gene Expression Regulation, Neoplastic
Gene silencing
Genetic aspects
Genomes
Health aspects
Hepatocellular carcinoma
Hepatocytes
Humans
Kidney cancer
Kidney Neoplasms - genetics
Liver cancer
Liver diseases
lnc-uc.147
lncRNAs
RNA, Long Noncoding - genetics
Software
Solid tumors
Statistical analysis
T-UCRs
TEA domain transcription factor 4
TEA Domain Transcription Factors
Transcription factors
Tumor staging
uc.147
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Summary:Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study aimed to investigate lnc-uc.147 in different types of cancer, as well as to suggest lnc-uc.147 functional and regulation aspects. From solid tumor datasets analysis of The Cancer Genome Atlas (TCGA), deregulated lnc-uc.147 expression was associated with the histologic grade of hepatocellular carcinoma, and with the tumor stage of clear cell renal and gastric adenocarcinoma. Considering the epidemiologic relevance of liver cancer, silencing lnc-uc.147 reduced the viability and clonogenic capacity of HepG2 cell lines. Additionally, we suggest a relation between the transcription factor TEAD4 and lnc-uc.147 in liver and breast cancer cells.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13020265