Side Effects of COVID-19 Vaccines Primer Doses: Experience of Saudi Healthcare Workers Participating in CoVaST-SA

Side effects emerging after COVID-19 vaccines may adversely impact public confidence in vaccines. Therefore, this study was designed to explore the short-term side effects of COVID-19 vaccines as a part of the COVID-19 Vaccines Safety Tracking (CoVaST) study. A cross-sectional survey-based study was...

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Bibliographic Details
Published in:Vaccines (Basel) 2022-12, Vol.10 (12), p.2137
Main Authors: Riad, Abanoub, Alsaad, Safa S, Almurikhi, Ali A, Alzahrani, Fayez A, Alghamdi, Ali M, Alzaid, Esra H, Klugar, Miloslav
Format: Article
Language:English
Subjects:
Adverse and side effects
Coronaviruses
CoVaST
COVID-19
COVID-19 vaccines
drug-related side effects and adverse reactions
Drugs
Evaluation
Females
Health aspects
Health care
health personnel
Immunization
Medical personnel
mRNA
Public concern
Safety
Saudi Arabia
Schedules
Side effects
Vaccines
Viral diseases
Womens health
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Summary:Side effects emerging after COVID-19 vaccines may adversely impact public confidence in vaccines. Therefore, this study was designed to explore the short-term side effects of COVID-19 vaccines as a part of the COVID-19 Vaccines Safety Tracking (CoVaST) study. A cross-sectional survey-based study was carried out to collect data from healthcare workers (HCWs) in Saudi Arabia. The study was initiated between June and December 2021. A validated questionnaire was used in this study consisting of four categories, including demographic characteristics and medical anamnesis of the participants, COVID-19-associated anamnesis, and side effects of vaccine uptake. The study included 1039 participants, of which 70.2% were females, and their median age was 34. About 82.9% and 52.3% of the participants reported a minimum of both one local and systemic side effect, respectively. Females, young participants (≤34 years old), and non-obese participants had more potential to disclose post-vaccination side effects than their counterparts. Heterologous schedules and viral vector-based vaccines were linked with a greater rate of systemic side effects, whereas homologous vaccination schedules and mRNA-based vaccines were linked with a greater rate of local side effects. Future studies on COVID-19 vaccines should focus on the role of BMI, previous infection, and vaccination schedule in terms of vaccine safety and reactogenicity.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines10122137