Proanthocyanidins supplemented diet alter anti-aging-markers and improved lifespan in Drosophila melanogaster model

• Published in: Beni-Suef University journal of basic and applied sciences 2024-12, Vol.13 (1), p.11-10, Article 11
• Main Authors: Jaafaru, Mohammed Sani, Muhammad, Suleiman Alhaji, Mohammed, Zainab Kasim, Aliyu, Yakubu, Razis, Ahmad Faizal Abdull
• Format: Article
• Language: English
• Subjects: Acetylcholinesterase; Age related diseases; Aging; Aging (natural); Anti-aging markers; Antioxidants; Assaying; Caspase-3; Caspase-9; Catalase; Diet; Drosophila melanogaster; Eclosion; Enzymes; Flavonoids; Fruit flies; Geotaxis; Glutathione; Glutathione transferase; Hydroxyl groups; Insects; Life span; Longevity; Medicine; Medicine & Public Health; Mortality; Neuroprotection; Nicotinamide; Oxidative stress; Phytochemicals; Plants; Proanthocyanidins; Proteins; Quality of life; Quinone oxidoreductase; Quinones; Robustness; Superoxide dismutase; Tamarindus indica
• ISSN: 2314-8543; 2314-8535; 2314-8543
• DOI: 10.1186/s43088-024-00469-x

Background It is unequivocally believed that phenolics and flavonoids from fruits and vegetables hold robust prevention potentials against age-related disease development through their abundant hydroxyl groups. This study explored the potential neuromuscular enhancement and anti-aging effects of dietary supplemented proanthocyanidins-rich fraction from Tamarindus indica on Drosophila melanogaster model. One- to three-day-old male and female D. melanogaster were fed with a proanthocyanidins-rich fraction-supplemented diet for 7 days at two different concentrations. Following the effective dose determination, longevity assay (rate of survival), behavioral assay (negative geotaxis and eclosion), and biochemical assays (aging and antioxidant enzymes activities) were conducted to assess the fraction’s longevity, antioxidant, and anti-aging effects on D. melanogaster model. Result The results showed a significant ( p