Frequency and Molecular Characterization of Staphylococcus aureus from Placenta of Mothers with Term and Preterm Deliveries

• Published in: Life (Basel, Switzerland) Switzerland), 2022-02, Vol.12 (2), p.257
• Main Authors: Farooqi, Hafiz Muhammad Umer, Kim, Kyung-Hwan, Kausar, Farzana, Muhammad, Javed, Bukhari, Habib, Choi, Kyung-Hyun
• Format: Article
• Language: English
• Subjects: Antibiotics; Antiinfectives and antibacterials; Cefoxitin; Colonization; Comparative studies; Drug resistance; Genes; Infant mortality; Intestinal microflora; Life cycles; MecA protein; Methicillin; methicillin-resistant Staphylococcus aureus (MRSA); Microbiota; Microorganisms; Mortality; Neonates; Ofloxacin; Oxacillin; Penicillin; Placenta; Premature birth; preterm; Public health; Staphylococcus aureus; Staphylococcus aureus (S. aureus); Staphylococcus infections; Sulfamethoxazole; term; Trimethoprim; Trimethoprim-sulfamethoxazole; Womens health
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life12020257

Globally, prematurity is the leading cause of neonatal mortality (babies in the first four weeks of life) and now the second leading cause of mortality after pneumonia in children under age five. The neonatal gut microbial colonization is crucial in the human life cycle. Placental microbiota transmits from the gut microbiota plays a significant role in association with kinship. Simultaneously, this transition is being made from mother to infant. This comparative study explored the diversity of microbiota associated with term and preterm neonates by evaluating the placental samples. The study found that 16/68 (23.5%) full-term placental samples were positive for on the other hand, 4/16 (25%) preterm placental samples confirmed culture growth for Antimicrobial susceptibility patterns showed that ( ) isolates from both types of samples were resistant to Ofloxacin, Trimethoprim-sulfamethoxazole, Oxacillin, and Cefoxitin. However, Methicillin-Resistant (MRSA) detection was 43.75% in full-term and 75% in preterm placental samples. Moreover, two isolates were positive for both and virulent genes, and the rest were positive only for the gene. Interestingly few isolates lacked both characteristic MRSA genes, and . Notably, resistances were more inclined towards preterm samples for antimicrobial susceptibility and MRSA screening. It may be concluded that there is a significant presence of in the placenta of mothers with term and preterm deliveries which might be responsible for preterm deliveries. Therefore, judicious use of antibiotics during pregnancies may help prevent preterm births.