The case for increasing diversity in tissue-based functional genomics datasets to understand human disease susceptibility

Tissue-based functional genomics resources including molecular quantitative trait loci datasets lack diversity in ancestry and tissue types and thus are inadequate for comprehensively investigating gene regulation. Global efforts to increase the tissue diversity will help achieve more equitable medi...

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Bibliographic Details
Published in:Nature communications 2022-05, Vol.13 (1), p.2907-2907, Article 2907
Main Authors: Long, Erping, García-Closas, Montserrat, Chanock, Stephen J., Camargo, M. Constanza, Banovich, Nicholas E., Choi, Jiyeon
Format: Article
Language:English
Subjects:
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38/43
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631/208/191/2018
631/208/457/649
Comment
Datasets
Gene mapping
Gene regulation
Genomics
Humanities and Social Sciences
multidisciplinary
Quantitative trait loci
Science
Science (multidisciplinary)
Tissues
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Description
Summary:Tissue-based functional genomics resources including molecular quantitative trait loci datasets lack diversity in ancestry and tissue types and thus are inadequate for comprehensively investigating gene regulation. Global efforts to increase the tissue diversity will help achieve more equitable medical care.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-022-30650-8