Infection With Escherichia Coli Pathotypes Is Associated With Biomarkers of Gut Enteropathy and Nutritional Status Among Malnourished Children in Bangladesh

( ) pathotypes are the most common cause of diarrhea, especially in developing countries. Environmental Enteric Dysfunction (EED) is presumed to be the result of infection with one or more pathotypes and can affect intestinal health and childhood growth. We sought to investigate the association of p...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2022-07, Vol.12, p.901324
Main Authors: Gazi, Md Amran, Alam, Md Ashraful, Fahim, Shah Mohammad, Wahid, Barbie Zaman, Khan, Shaila Sharmeen, Islam, Md Ohedul, Hasan, Md Mehedi, Hasan, S M Tafsir, Das, Subhasish, Mahfuz, Mustafa, Haque, Rashidul, Ahmed, Tahmeed
Format: Article
Language:English
Subjects:
Bangladesh
Bangladesh - epidemiology
Biomarkers
Cellular and Infection Microbiology
Child
diarrhea
Diarrhea - epidemiology
environmental enteric dysfunction
Escherichia coli
Escherichia coli - genetics
Escherichia coli Infections - epidemiology
Feces
Humans
Intestinal Diseases
Leukocyte L1 Antigen Complex
malnutrition
Neopterin
Nutritional Status
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:( ) pathotypes are the most common cause of diarrhea, especially in developing countries. Environmental Enteric Dysfunction (EED) is presumed to be the result of infection with one or more pathotypes and can affect intestinal health and childhood growth. We sought to investigate the association of pathotypes infection with biomarkers of EED and nutritional status among slum-dwelling malnourished children in Bangladesh. This study comprised a total of 1050 stunted and at risk of stunting children. TaqMan Array Card assays were used to determine the presence of pathotypes in feces. Prevalence of infection with EAEC was highest (68.8%) in this cohort of children, followed by EPEC (55.9%), ETEC (44%), Shigella/EIEC (19.4%) and STEC (3.2%). The levels of myeloperoxidase and calprotectin were significantly higher in EAEC (P=0.02 and P=0.04), EPEC (P=0.02 and P=0.03) and Shigella/EIEC (P=0.05 and P=0.02) positive participants while, only calprotectin was significantly higher in ETEC (P=0.01) positive participants. Reg1B was significantly higher in participants with EAEC (P=0.004) while, neopterin levels were significantly lower in ETEC (P=0.003) and Shigella/EIEC (P=0.003) positive cases. A significant positive relationship was observed between EAEC and fecal levels of Reg1B (β = 0.28; 95% CI = 0.12, 0.43; p-value
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.901324