Successful Treatment of Recurrent Primary Sclerosing Cholangitis after Orthotopic Liver Transplantation with Oral Vancomycin

Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis...

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Bibliographic Details
Published in:Case reports in transplantation 2013-01, Vol.2013 (2013), p.1-5
Main Authors: Davies, Yinka K., Tsay, Cynthia J., Caccamo, Dario V., Cox, Kathleen M., Castillo, Ricardo O., Cox, Kenneth L.
Format: Article
Language:English
Subjects:
Autoimmune diseases
Bacteria
Case Report
Gallbladder diseases
Hepatology
Hypertension
Inflammatory bowel disease
Liver cirrhosis
Liver diseases
Mortality
Pathogenesis
Patients
Pediatrics
Transplants & implants
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Summary:Primary sclerosing cholangitis (PSC) is a progressive, cholestatic disease of the liver that is marked by inflammation of the bile ducts and damage to the hepatic biliary tree. Approximately 60–70% of patients also have inflammatory bowel disease and progression of PSC can lead to ulcerative colitis and cirrhosis of the liver. Due to limited understanding of the etiology and mechanism of PSC, the only existing treatment option is orthotopic liver transplantation (OLT); however, recurrence of PSC, after OLT is estimated to be between 5% and 35%. We discuss the successful treatment of a pediatric patient, with recurrent PSC, after OLT with oral Vancomycin.
ISSN:2090-6943
2090-6951
DOI:10.1155/2013/314292