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Advancements in Research on Mesenchymal Stem-Cell-Derived Exosomal miRNAs: A Pivotal Insight into Aging and Age-Related Diseases
Mesenchymal stem cells (MSCs) are capable of differentiating into various cell types and play a crucial role in repairing aging tissues and diseased organs. Aging manifests as a gradual loss of cellular, tissue, and organ function, leading to the progression of pathologies. Exosomes (Exos) are extra...
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Published in: | Biomolecules (Basel, Switzerland) Switzerland), 2024-10, Vol.14 (11), p.1354 |
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description | Mesenchymal stem cells (MSCs) are capable of differentiating into various cell types and play a crucial role in repairing aging tissues and diseased organs. Aging manifests as a gradual loss of cellular, tissue, and organ function, leading to the progression of pathologies. Exosomes (Exos) are extracellular vesicles secreted by cells, which maintain cellular homeostasis, clear cellular debris, and facilitate communication between cells and organs. This review provides a comprehensive summary of the mechanisms for the synthesis and sorting of MSC-Exo miRNAs and summarizes the current research status of MSCs-Exos in mitigating aging and age-related diseases. It delves into the underlying molecular mechanisms, which encompass antioxidative stress, anti-inflammatory response, and the promotion of angiogenesis. Additionally, this review also discusses potential challenges in and future strategies for advancing MSC-Exo miRNA-based therapies in the treatment of aging and age-related diseases. |
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Aging manifests as a gradual loss of cellular, tissue, and organ function, leading to the progression of pathologies. Exosomes (Exos) are extracellular vesicles secreted by cells, which maintain cellular homeostasis, clear cellular debris, and facilitate communication between cells and organs. This review provides a comprehensive summary of the mechanisms for the synthesis and sorting of MSC-Exo miRNAs and summarizes the current research status of MSCs-Exos in mitigating aging and age-related diseases. It delves into the underlying molecular mechanisms, which encompass antioxidative stress, anti-inflammatory response, and the promotion of angiogenesis. 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Aging manifests as a gradual loss of cellular, tissue, and organ function, leading to the progression of pathologies. Exosomes (Exos) are extracellular vesicles secreted by cells, which maintain cellular homeostasis, clear cellular debris, and facilitate communication between cells and organs. This review provides a comprehensive summary of the mechanisms for the synthesis and sorting of MSC-Exo miRNAs and summarizes the current research status of MSCs-Exos in mitigating aging and age-related diseases. It delves into the underlying molecular mechanisms, which encompass antioxidative stress, anti-inflammatory response, and the promotion of angiogenesis. 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metabolism</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>miRNAs</subject><subject>Molecular modelling</subject><subject>Proteins</subject><subject>Public health</subject><subject>Review</subject><subject>RNA polymerase</subject><subject>Senescence</subject><subject>Stem cell research</subject><subject>Stem cells</subject><issn>2218-273X</issn><issn>2218-273X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEolXpjTOKxIUDKbYnThwuKNoWulL50AISN8uxJ1mvEruNsyt646fj7Zayi7AteTR-5xnPaJLkOSVnABV501g_0JxSCjx_lBwzRkXGSvjxeM8-Sk5DWJG4RDwMniZHUPGKc6DHya_abJTTOKCbQmpdusCAatTL1Lv0Y7SdXt4Oqk-_TjhkM-z77BxHu0GTXvz0wW-fBrv4VIe3aZ1-sRs_Rc_cBdstp8ibfFp31nWpciZamC2wV1OMPrcxT8DwLHnSqj7g6f19knx_f_Ftdpldff4wn9VXmY6fnTKqCk5oji0UhJfQ6IoLxfKyqFoNBRguKDWVaowQDSida0EqRnUrWIllqQycJPMd13i1ktejHdR4K72y8s7hx06qcbK6R2kM0KZoAUhR5aVoFGsFlMg4QcHbsoysdzvW9boZ0OjYu1H1B9DDF2eXsvMbSSmvWORGwqt7wuhv1hgmOdigY3eVQ78OEihAzjmDbbKX_0hXfj262KutilVVwbn4q-pUrMC61sfEeguVtaCCEiCERdXZf1RxGxys9g5bG_0HAa93AXr0IYzYPhRJidxOoNyfwCh_sd-YB_GfeYPfBY_UUA</recordid><startdate>20241024</startdate><enddate>20241024</enddate><creator>Huang, Minglei</creator><creator>Liu, Ye</creator><creator>Zhang, Longze</creator><creator>Wang, Shuangmin</creator><creator>Wang, Xianyao</creator><creator>He, Zhixu</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1742-2045</orcidid><orcidid>https://orcid.org/0009-0004-6327-9413</orcidid></search><sort><creationdate>20241024</creationdate><title>Advancements in Research on Mesenchymal Stem-Cell-Derived Exosomal miRNAs: A Pivotal Insight into Aging and Age-Related Diseases</title><author>Huang, Minglei ; Liu, Ye ; Zhang, Longze ; Wang, Shuangmin ; Wang, Xianyao ; He, Zhixu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-1a65014ef360573bc958a24769fc363d5811d9abd88b3ac4c80921cf827e77ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aging</topic><topic>Aging - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Biomolecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Minglei</au><au>Liu, Ye</au><au>Zhang, Longze</au><au>Wang, Shuangmin</au><au>Wang, Xianyao</au><au>He, Zhixu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advancements in Research on Mesenchymal Stem-Cell-Derived Exosomal miRNAs: A Pivotal Insight into Aging and Age-Related Diseases</atitle><jtitle>Biomolecules (Basel, Switzerland)</jtitle><addtitle>Biomolecules</addtitle><date>2024-10-24</date><risdate>2024</risdate><volume>14</volume><issue>11</issue><spage>1354</spage><pages>1354-</pages><issn>2218-273X</issn><eissn>2218-273X</eissn><abstract>Mesenchymal stem cells (MSCs) are capable of differentiating into various cell types and play a crucial role in repairing aging tissues and diseased organs. 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subjects | Aging Aging - genetics Aging - metabolism aging-related diseases Angiogenesis Animals Cell differentiation Cell interactions Chemokines Communication Cytochrome Cytokines Development and progression Diseases Enzymes Exosomes Exosomes - genetics Exosomes - metabolism Extracellular vesicles Growth factors Homeostasis Humans Inflammation Liu, Timothy Mesenchymal stem cells Mesenchymal Stem Cells - metabolism MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA miRNAs Molecular modelling Proteins Public health Review RNA polymerase Senescence Stem cell research Stem cells |
title | Advancements in Research on Mesenchymal Stem-Cell-Derived Exosomal miRNAs: A Pivotal Insight into Aging and Age-Related Diseases |
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