Pan-cancer integrated analysis of ANKRD1 expression, prognostic value, and potential implications in cancer

There is substantial evidence demonstrating the crucial role of inflammation in oncogenesis. ANKRD1 has been identified as an anti-inflammatory factor and is related to tumor drug resistance. However, there have been no studies investigating the prognostic value and molecular function of ANKRD1 in p...

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Published in:Scientific reports 2024-03, Vol.14 (1), p.5268-5268, Article 5268
Main Authors: Xu, Xusan, Zhong, Dan, Wang, Xiaoxia, Luo, Fei, Zheng, Xiaomei, Feng, Taoshan, Chen, Riling, Cheng, Yisen, Wang, Yajun, Ma, Guoda
Format: Article
Language:English
Subjects:
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Apoptosis
Caco-2 Cells
Cancer
Carcinogenesis
Colorectal carcinoma
Correlation analysis
Deoxyribonucleic acid
DNA
DNA methylation
Drug development
Drug resistance
Humanities and Social Sciences
Humans
Immune checkpoint
Immunosuppressive agents
Infiltration
Inflammation
Leukocyte migration
Macrophages
Metastases
miRNA
multidisciplinary
Muscle Proteins
Nomograms
Nuclear Proteins - genetics
Prognosis
Regression analysis
Repressor Proteins
Science
Science (multidisciplinary)
Therapeutic targets
Tumor cell lines
Tumorigenesis
Tumors
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Summary:There is substantial evidence demonstrating the crucial role of inflammation in oncogenesis. ANKRD1 has been identified as an anti-inflammatory factor and is related to tumor drug resistance. However, there have been no studies investigating the prognostic value and molecular function of ANKRD1 in pan-cancer. In this study, we utilized the TCGA, GTEx, GSCALite, ENCORI, CTRP, DAVID, AmiGO 2, and KEGG databases as well as R language, to explore and visualize the role of ANKRD1 in tumors. We employed the ROC curve to explore its diagnostic significance, while the Kaplan–Meier survival curve and Cox regression analysis were used to investigate its prognostic value. Additionally, we performed Pearson correlation analysis to evaluate the association between ANKRD1 expression and DNA methylation, immune cell infiltration, immune checkpoints, TMB, MSI, MMR, and GSVA. Our findings indicate that ANKRD1 expression is dysregulated in pan-cancer. The ROC curve revealed that ANKRD1 expression is highly sensitive and specific in diagnosing CHOL, LUAD, LUSC, PAAD, SKCM, and UCS (AUC > 85.0%, P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-56105-2