Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet

Hepatic lipase (HL) plays a central role in LDL and HDL remodeling. High HL activity is associated with small, dense LDL particles and with reduced HDL2 cholesterol levels. HL activity is determined by an HL gene promoter polymorphism, by gender (lower in premenopausal women), and by visceral obesit...

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Published in:Journal of lipid research 2003-07, Vol.44 (7), p.1279-1286
Main Authors: Deeb, Samir S, Zambon, Alberto, Carr, Molly C, Ayyobi, Amir F, Brunzell, John D
Format: Article
Language:English
Subjects:
atherosclerosis
Diabetes Mellitus, Type 2 - genetics
Diet
Female
Genetic Variation
Haplotypes
hepatic lipase genetics
Humans
hyperlipidemia
Hyperlipidemia, Familial Combined - genetics
Hyperlipidemias - enzymology
Hyperlipidemias - genetics
Lipase - genetics
Lipase - physiology
Lipoproteins, LDL - metabolism
Liver - enzymology
Male
Models, Biological
Obesity - genetics
Obesity - metabolism
Polymorphism, Genetic
Promoter Regions, Genetic
Sex Factors
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Summary:Hepatic lipase (HL) plays a central role in LDL and HDL remodeling. High HL activity is associated with small, dense LDL particles and with reduced HDL2 cholesterol levels. HL activity is determined by an HL gene promoter polymorphism, by gender (lower in premenopausal women), and by visceral obesity with insulin resistance. The activity is affected by dietary fat intake and selected medications. There is evidence for an interaction of the HL promoter polymorphism with visceral obesity, dietary fat intake, and with lipid-lowering medications in determining the level of HL activity. The dyslipidemia with high HL activity is a potentially proatherogenic lipoprotein profile in the metabolic syndrome, in Type 2 diabetes, and in familial combined hyperlipidemia.
ISSN:0022-2275
DOI:10.1194/jlr.r200017-jlr200