Positive Echocardiographic Association between Carotid Artery and Coronary Artery Diameter and Z-Score in a Mouse Model of Kawasaki Disease

Kawasaki disease (KD) occurs in young children, has an unknown etiology, and can cause such life-threatening complications as coronary artery aneurysm. A mouse model using cell wall extract (LCWE) with intraperitoneal injection was established for KD years ago. Histological examination of coronary a...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostics (Basel) 2024-01, Vol.14 (2), p.145
Main Authors: Shih, Wen-Ling, Yeh, Tsung-Ming, Chen, Kuang-Den, Leu, Steve, Kuo, Ho-Chang
Format: Article
Language:English
Subjects:
Aneurysms
animal model
Carotid arteries
carotid artery
coronary artery
Coronary vessels
Kawasaki disease
Kinases
Laboratory animals
Lactobacillus casei
Mice
Pathogenesis
Standard scores
Surveys
Ultrasonic imaging
Veins & arteries
Z score
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kawasaki disease (KD) occurs in young children, has an unknown etiology, and can cause such life-threatening complications as coronary artery aneurysm. A mouse model using cell wall extract (LCWE) with intraperitoneal injection was established for KD years ago. Histological examination of coronary artery lesions indicated features similar to those of vascular lesions of patients with KD. Since animals must be sacrificed during histological examination, the longitudinal survey of coronary artery lesions (CALs) is difficult. The aim of this study was to survey the vasculitis status of the coronary artery and the carotid artery in a KD mouse model. LCWE was intraperitoneally injected into 5-week-old male C57BL/6 mice to induce CALs. We studied the longitudinal status of the carotid and coronary arteries and analyzed the Z-score of coronary artery diameter. Carotid artery wall thickness (day 7) and diameter (day 14) significantly increased in the LCWE group with a dose-dependent effect ( < 0.05). Aortic diameter and wall thickness demonstrated significant increases on day 28 and day 7, respectively ( < 0.05). Carotid artery outer diameter and wall thickness were positively associated with coronary artery diameter on day 28 ( < 0.01). Coronary artery diameter significantly increased in the LCWE group after day 7 ( < 0.05). The percentage of Z > 3.0 indicated was more than 80% in the high-dose LCWE group and 0% in the control group. This report is the first to use coronary artery Z-score in a mouse model of KD by echocardiography and to find a positive association between carotid artery and coronary artery diameter.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14020145