Bronchoconstriction: a potential missing link in airway remodelling

In asthma, progressive structural changes of the airway wall are collectively termed airway remodelling. Despite its deleterious effect on lung function, airway remodelling is incompletely understood. As one of the important causes leading to airway remodelling, here we discuss the significance of m...

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Bibliographic Details
Published in:Open biology 2020-12, Vol.10 (12), p.200254
Main Authors: O'Sullivan, Michael J, Phung, Thien-Khoi N, Park, Jin-Ah
Format: Article
Language:English
Subjects:
Airway Remodeling
airway remodelling
Animals
asthma
Biomarkers
Bronchoconstriction
Disease Management
Disease Progression
Disease Susceptibility
Humans
mechanical stress
Respiratory Mucosa - immunology
Respiratory Mucosa - metabolism
Respiratory Mucosa - pathology
Review
Signal Transduction
Stress, Mechanical
Stress, Physiological
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Summary:In asthma, progressive structural changes of the airway wall are collectively termed airway remodelling. Despite its deleterious effect on lung function, airway remodelling is incompletely understood. As one of the important causes leading to airway remodelling, here we discuss the significance of mechanical forces that are produced in the narrowed airway during asthma exacerbation, as a driving force of airway remodelling. We cover , and work in this field, and discuss up-to-date literature supporting the idea that bronchoconstriction may be the missing link in a comprehensive understanding of airway remodelling in asthma.
ISSN:2046-2441
2046-2441
DOI:10.1098/rsob.200254