Epstein-Barr Virus and Human Herpesvirus 8 in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic and uniformly fatal interstitial lung disease with incompletely understood pathogenesis. Several studies have given the evidence for and against viral cofactors in the pathogenesis of Idiopathic pulmonary fibrosis. In this study (EBV) and (HHV-8) have...

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Bibliographic Details
Published in:Iranian journal of pathology 2020, Vol.15 (1), p.30-33
Main Authors: Jafarian, Amir Hossein, Mohamadian Roshan, Nema, Ayatollahi, Hossein, Omidi, Abbas Ali, Ghaznavi, Masoumeh, Gharib, Masoumeh
Format: Article
Language:English
Subjects:
epstein - barr virus
human herpesvirus 8
idiopathic pulmonary fibrosis
Original
polymerase chain reaction
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Summary:Idiopathic pulmonary fibrosis (IPF) is a chronic and uniformly fatal interstitial lung disease with incompletely understood pathogenesis. Several studies have given the evidence for and against viral cofactors in the pathogenesis of Idiopathic pulmonary fibrosis. In this study (EBV) and (HHV-8) have been studied for a possible role in the pathogenesis of IPF. Polymerase chain reaction (PCR) was employed for the detection of EBV and HHV-8 in 58 formalin-fixed paraffin-embedded lung tissue specimens (29 controls and 29 IPF specimens). EBV DNA was present in the lung tissue of 6 out of 29 (20.7%) IPF specimens compared with 1 out of 29 (3.4%) controls ( =0.102). The HHV-8 gene was identified in 3 out of 29 (10.3%) cases of IPF specimens. The control group showed no evidence of HHV-8 gene ( =0.227). Although multiple studies are strongly suggestive of a role for EBV and HHV-8 in the development of IPF, there was no statistically significant difference in the prevalence of EBV and HHV-8 DNA in the IPF specimens and controls in this study.
ISSN:1735-5303
2345-3656
DOI:10.30699/IJP.2019.77233.1728