Epidemiological and clinical characteristics of patients hospitalised with COVID-19 in Kenya: a multicentre cohort study

ObjectivesTo assess outcomes of patients admitted to hospital with COVID-19 and to determine the predictors of mortality.SettingThis study was conducted in six facilities, which included both government and privately run secondary and tertiary level facilities in the central and coastal regions of K...

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Bibliographic Details
Published in:BMJ open 2022-05, Vol.12 (5), p.e049949-e049949
Main Authors: Ombajo, Loice Achieng, Mutono, Nyamai, Sudi, Paul, Mutua, Mbuvi, Sood, Mohammed, Loo, Alliyy Muhammad, Juma, Phoebe, Odhiambo, Jackline, Shah, Reena, Wangai, Frederick, Maritim, Marybeth, Anzala, Omu, Amoth, Patrick, Kamuri, Evans, Munyu, Waweru, Thumbi, S M
Format: Article
Language:English
Subjects:
Age
Asymptomatic
Cohort analysis
Coronaviruses
COVID-19
COVID-19 diagnostic tests
Dehydrogenases
Diabetes
diabetes & endocrinology
Disease transmission
epidemiology
Fatalities
Health facilities
Hospitals
Illnesses
Infectious Diseases
intensive & critical care
Laboratories
Medical personnel
Medical records
Mortality
Palliative care
Patients
public health
Severe acute respiratory syndrome coronavirus 2
Survival analysis
Ventilators
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Summary:ObjectivesTo assess outcomes of patients admitted to hospital with COVID-19 and to determine the predictors of mortality.SettingThis study was conducted in six facilities, which included both government and privately run secondary and tertiary level facilities in the central and coastal regions of Kenya.ParticipantsWe enrolled 787 reverse transcriptase-PCR-confirmed SARS-CoV2-infected persons. Patients whose records could not be accessed were excluded.Primary and secondary outcome measuresThe primary outcome was COVID-19-related death. We used Cox proportional hazards regressions to determine factors related to in-hospital mortality.ResultsData from patients with 787 COVID-19 were available. The median age was 43 years (IQR 30–53), with 505 (64%) being men. At admission, 455 (58%) were symptomatic with an additional 63 (9%) developing clinical symptoms during hospitalisation. The most common symptoms were cough (337, 43%), loss of taste or smell (279, 35%) and fever (126, 16%). Comorbidities were reported in 340 (43%), with cardiovascular disease, diabetes and HIV documented in 130 (17%), 116 (15%), 53 (7%), respectively. 90 (11%) were admitted to the Intensive Care Unit (ICU) for a mean of 11 days, 52 (7%) were ventilated with a mean of 10 days, 107 (14%) died. The risk of death increased with age (HR 1.57 (95% CI 1.13 to 2.19)) for persons >60 years compared with those
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2021-049949