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Chemoembolization follow-up of hepatocellular carcinoma with diffusion-weighted MR imaging
To assess the treatment response of hepatocellular carcinoma (HCC) after transarterial chemoembolization with diffusion weighted magnetic resonance (MR) imaging with a 1.5T system. Thirty patients with 30 HCC focal lesions were prospectively evaluated for early treatment response after transarterial...
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Published in: | Egyptian journal of radiology and nuclear medicine 2015-12, Vol.46 (4), p.871-878 |
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container_title | Egyptian journal of radiology and nuclear medicine |
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description | To assess the treatment response of hepatocellular carcinoma (HCC) after transarterial chemoembolization with diffusion weighted magnetic resonance (MR) imaging with a 1.5T system.
Thirty patients with 30 HCC focal lesions were prospectively evaluated for early treatment response after transarterial chemoembolization using dynamic contrast enhanced MRI and diffusion weighted MRI before and after the procedure. Diameter of arterially enhancing portions and apparent diffusion coefficient (ADC) values of lesions were recorded. The significance of differences between ADC values of completely responding and partially responding lesions was calculated.
Tumor ADC value increased from 1.2+0.1×103mm2/s to 1.49+0.3×103mm2/s after treatment (p |
doi_str_mv | 10.1016/j.ejrnm.2015.06.019 |
format | article |
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Thirty patients with 30 HCC focal lesions were prospectively evaluated for early treatment response after transarterial chemoembolization using dynamic contrast enhanced MRI and diffusion weighted MRI before and after the procedure. Diameter of arterially enhancing portions and apparent diffusion coefficient (ADC) values of lesions were recorded. The significance of differences between ADC values of completely responding and partially responding lesions was calculated.
Tumor ADC value increased from 1.2+0.1×103mm2/s to 1.49+0.3×103mm2/s after treatment (p<0.001). There was a significant positive correlation between the percent change in the mean ADC and the percent change in the diameter of the enhancing tumor tissue after chemoembolization. The best predictive cutoff value for differentiation between complete and partial response was 24% change in the mean ADC.
Responding HCC lesions exhibited decreases in arterial enhancement and increases in ADC values. Percent change in the mean ADC values was predictive of response to chemoembolization.</description><identifier>ISSN: 0378-603X</identifier><identifier>DOI: 10.1016/j.ejrnm.2015.06.019</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Diffusion weighted MR imaging (DWI) ; Dynamic contrast enhanced MRI ; Hepatocellular carcinoma (HCC) ; Magnetic resonance imaging (MRI) ; Transarterial chemoembolization (TACE)</subject><ispartof>Egyptian journal of radiology and nuclear medicine, 2015-12, Vol.46 (4), p.871-878</ispartof><rights>2015 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c364t-f3d4bf392e380367d625d7ba8fa9052808ae2a2c7a6465910db2d8e92f4b98f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378603X15001394$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids></links><search><creatorcontrib>Ibrahim, Yosra Abdelzaher</creatorcontrib><creatorcontrib>ElGharib, Mohamed</creatorcontrib><creatorcontrib>Sheha, Dina Sayed</creatorcontrib><title>Chemoembolization follow-up of hepatocellular carcinoma with diffusion-weighted MR imaging</title><title>Egyptian journal of radiology and nuclear medicine</title><description>To assess the treatment response of hepatocellular carcinoma (HCC) after transarterial chemoembolization with diffusion weighted magnetic resonance (MR) imaging with a 1.5T system.
Thirty patients with 30 HCC focal lesions were prospectively evaluated for early treatment response after transarterial chemoembolization using dynamic contrast enhanced MRI and diffusion weighted MRI before and after the procedure. Diameter of arterially enhancing portions and apparent diffusion coefficient (ADC) values of lesions were recorded. The significance of differences between ADC values of completely responding and partially responding lesions was calculated.
Tumor ADC value increased from 1.2+0.1×103mm2/s to 1.49+0.3×103mm2/s after treatment (p<0.001). There was a significant positive correlation between the percent change in the mean ADC and the percent change in the diameter of the enhancing tumor tissue after chemoembolization. The best predictive cutoff value for differentiation between complete and partial response was 24% change in the mean ADC.
Responding HCC lesions exhibited decreases in arterial enhancement and increases in ADC values. Percent change in the mean ADC values was predictive of response to chemoembolization.</description><subject>Diffusion weighted MR imaging (DWI)</subject><subject>Dynamic contrast enhanced MRI</subject><subject>Hepatocellular carcinoma (HCC)</subject><subject>Magnetic resonance imaging (MRI)</subject><subject>Transarterial chemoembolization (TACE)</subject><issn>0378-603X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kM9O4zAQh3MAaSvgCfaSF0gY_4mTHDigChYkEBLisNqLNbHHraMkrpx0K_bpcemKI76MZM33zcwvy34yKBkwdd2X1MdpLDmwqgRVAmvPshWIuikUiN8_sqt57iE9CaldrrI_6y2NgcYuDP4fLj5MuQvDEA7FfpcHl29ph0swNAz7AWNuMBo_hRHzg1-2ufXO7ecEFQfym-1CNn9-zf2IGz9tLrNzh8NMV__rRfZ2f_e2fiieXn49rm-fCiOUXAonrOycaDmJBoSqreKVrTtsHLZQ8QYaJI7c1KikqloGtuO2oZY72bWNExfZ40lrA_Z6F9P0-K4Dev35EeJGY1y8GUhbqwxXDpRhtayZbRxYENxIKSpExZNLnFwmhnmO5L58DPQxYN3rz4D1MWANSqeAE3Vzoihd-ddT1LPxNBmyPpJZ0h7-W_4Dgd6IXA</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Ibrahim, Yosra Abdelzaher</creator><creator>ElGharib, Mohamed</creator><creator>Sheha, Dina Sayed</creator><general>Elsevier B.V</general><general>SpringerOpen</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope></search><sort><creationdate>20151201</creationdate><title>Chemoembolization follow-up of hepatocellular carcinoma with diffusion-weighted MR imaging</title><author>Ibrahim, Yosra Abdelzaher ; ElGharib, Mohamed ; Sheha, Dina Sayed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-f3d4bf392e380367d625d7ba8fa9052808ae2a2c7a6465910db2d8e92f4b98f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Diffusion weighted MR imaging (DWI)</topic><topic>Dynamic contrast enhanced MRI</topic><topic>Hepatocellular carcinoma (HCC)</topic><topic>Magnetic resonance imaging (MRI)</topic><topic>Transarterial chemoembolization (TACE)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ibrahim, Yosra Abdelzaher</creatorcontrib><creatorcontrib>ElGharib, Mohamed</creatorcontrib><creatorcontrib>Sheha, Dina Sayed</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian journal of radiology and nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ibrahim, Yosra Abdelzaher</au><au>ElGharib, Mohamed</au><au>Sheha, Dina Sayed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemoembolization follow-up of hepatocellular carcinoma with diffusion-weighted MR imaging</atitle><jtitle>Egyptian journal of radiology and nuclear medicine</jtitle><date>2015-12-01</date><risdate>2015</risdate><volume>46</volume><issue>4</issue><spage>871</spage><epage>878</epage><pages>871-878</pages><issn>0378-603X</issn><abstract>To assess the treatment response of hepatocellular carcinoma (HCC) after transarterial chemoembolization with diffusion weighted magnetic resonance (MR) imaging with a 1.5T system.
Thirty patients with 30 HCC focal lesions were prospectively evaluated for early treatment response after transarterial chemoembolization using dynamic contrast enhanced MRI and diffusion weighted MRI before and after the procedure. Diameter of arterially enhancing portions and apparent diffusion coefficient (ADC) values of lesions were recorded. The significance of differences between ADC values of completely responding and partially responding lesions was calculated.
Tumor ADC value increased from 1.2+0.1×103mm2/s to 1.49+0.3×103mm2/s after treatment (p<0.001). There was a significant positive correlation between the percent change in the mean ADC and the percent change in the diameter of the enhancing tumor tissue after chemoembolization. The best predictive cutoff value for differentiation between complete and partial response was 24% change in the mean ADC.
Responding HCC lesions exhibited decreases in arterial enhancement and increases in ADC values. Percent change in the mean ADC values was predictive of response to chemoembolization.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.ejrnm.2015.06.019</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Diffusion weighted MR imaging (DWI) Dynamic contrast enhanced MRI Hepatocellular carcinoma (HCC) Magnetic resonance imaging (MRI) Transarterial chemoembolization (TACE) |
title | Chemoembolization follow-up of hepatocellular carcinoma with diffusion-weighted MR imaging |
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