Glymphatic system dysfunction associated with cognitive impairment in chronic tinnitus patients

The glymphatic system has been regarded as a pivotal factor in the pathogenesis of neurodegenerative diseases. Given the heightened risk of cognitive impairment in chronic tinnitus patients, the possible alterations of the glymphatic system in tinnitus patients remain elusive. This study was designe...

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Bibliographic Details
Published in:Frontiers in neuroscience 2024-09, Vol.18, p.1455294
Main Authors: Du, Yinjuan, Huang, Zhichun, Wu, Yuanqing, Xue, Yuan, Che, Zigang
Format: Article
Language:English
Subjects:
chronic tinnitus
cognitive impairment
diffusion tensor imaging
glymphatic system
magnetic resonance imaging
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Summary:The glymphatic system has been regarded as a pivotal factor in the pathogenesis of neurodegenerative diseases. Given the heightened risk of cognitive impairment in chronic tinnitus patients, the possible alterations of the glymphatic system in tinnitus patients remain elusive. This study was designed to evaluate glymphatic dysfunction in chronic tinnitus patients using the diffusion tensor imaging (DTI) along the perivascular space (DTI-ALPS) approach. Fifty chronic tinnitus patients and 50 age, sex, and education-matched healthy controls (HCs) with normal hearing thresholds were recruited. The DTI-ALPS was calculated from each group. We investigated the differences in the DTI-ALPS index between the tinnitus patients and HCs. The relationships between the DTI-ALPS index and specific cognitive performance were further assessed. There were significant differences in the DTI-ALPS index between the two groups. The DTI-ALPS index was significantly lower in the tinnitus group than in HCs group (  
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2024.1455294