Antimicrobial Effect of Copper Nanoparticles on Relevant Supragingival Oral Bacteria

Copper nanoparticles (Cu NPs) show promise in dentistry for combating bacterial dysbiosis and tooth decay. Understanding their effects on commensal versus pathogenic bacteria is vital for maintaining oral health balance. While Cu NPs demonstrate antibacterial properties against various oral bacteria...

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Bibliographic Details
Published in:Microorganisms (Basel) 2024-03, Vol.12 (3), p.624
Main Authors: Oetiker, Nia, Salinas, Daniela, Lucero-Mora, Joaquín, Orellana, Rocío, Quiroz-Muñoz, Mariana, Bravo, Denisse, Pérez-Donoso, José M
Format: Article
Language:English
Subjects:
Alternative energy
Antimicrobial activity
Bacteria
biofilm
Biofilms
caries
Copper
Copper oxides
Cost analysis
Decay
Dental caries
Dental research
Dentistry
Dysbacteriosis
Health aspects
Lactobacillus
Microbiology
Mouth
Nanomaterials
Nanoparticles
Nanotechnology
Oral health
Oral hygiene
Pathogens
Streptococcus
Sucrose
Teeth
Toxicity
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Summary:Copper nanoparticles (Cu NPs) show promise in dentistry for combating bacterial dysbiosis and tooth decay. Understanding their effects on commensal versus pathogenic bacteria is vital for maintaining oral health balance. While Cu NPs demonstrate antibacterial properties against various oral bacteria, including common pathogens associated with tooth decay, their impact on commensal bacteria requires careful examination. In our work, we analyzed three types of Cu NPs for their effects on the growth, viability, and biofilm formation of representative caries-associated and commensal oral bacteria. showed high tolerance to all Cu NPs, while was highly sensitive. Oxide-Cu NPs exhibited a stronger inhibitory effect on pathobionts compared with commensal bacteria. Moreover, the biofilm formation of the key cariogenic bacteria was reduced, with minimal negative effects on commensal species' biofilm formation. All our results showed that CuO nanoparticles (CuO NPs) exhibit reduced toxicity toward commensal bacteria growth and development but have a strong impact on pathogens. This suggests their potential for targeted treatments against pathogenic bacteria, which could help in maintaining the balance of the oral bacterial community.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms12030624