Revealing the Role of High-Density Lipoprotein in Colorectal Cancer

Colorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology, which includes metabolic alterations as contributors to disease development. Studies have shown that lipid status disorders are involved in colorectal carcinogenesis. In line with this, previous studies have also...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-03, Vol.22 (7), p.3352
Main Authors: Zeljkovic, Aleksandra, Vekic, Jelena, Mihajlovic, Marija, Gojkovic, Tamara, Vladimirov, Sandra, Zeljkovic, Dejan, Spasojevic-Kalimanovska, Vesna, Trifunovic, Bratislav
Format: Article
Language:English
Subjects:
Atherosclerosis
Cancer therapies
Carcinogenesis
Carcinogens
Chemotherapy
Cholesterol
cholesterol trafficking
Colorectal cancer
Colorectal carcinoma
Disease
Etiology
genetic background
HDL functional properties
HDL particle distribution
High density lipoprotein
Lipids
Lipoproteins
Malignancy
Medical prognosis
Metabolism
Metastasis
MicroRNAs
Mutation
Obesity
Proteins
Review
Triglycerides
Tumors
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Summary:Colorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology, which includes metabolic alterations as contributors to disease development. Studies have shown that lipid status disorders are involved in colorectal carcinogenesis. In line with this, previous studies have also suggested that the serum high-density lipoprotein cholesterol (HDL-C) level decreases in patients with CRC, but more recently, the focus of investigations has shifted toward the exploration of qualitative properties of HDL in this malignancy. Herein, a comprehensive overview of available evidences regarding the putative role of HDL in CRC will be presented. We will analyze existing findings regarding alterations of HDL-C levels but also HDL particle structure and distribution in CRC. In addition, changes in HDL functionality in this malignancy will be discussed. Moreover, we will focus on the genetic regulation of HDL metabolism, as well as the involvement of HDL in disturbances of cholesterol trafficking in CRC. Finally, possible therapeutic implications related to HDL will be presented. Given the available evidence, future studies are needed to resolve all raised issues concerning the suggested protective role of HDL in CRC, its presumed function as a biomarker, and eventual therapeutic approaches based on HDL.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22073352