Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer

• Published in: International journal of molecular sciences 2019-03, Vol.20 (5), p.1180
• Main Authors: Kujundžić, Renata Novak, Stepanić, Višnja, Milković, Lidija, Gašparović, Ana Čipak, Tomljanović, Marko, Trošelj, Koraljka Gall
• Format: Article
• Language: English
• Subjects: Abuse; Age; Aging; Aging - drug effects; Animals; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Body weight; cancer; Chemokines; Chronic illnesses; Curcuma - chemistry; Curcumin; Curcumin - chemistry; Curcumin - pharmacology; Curcumin - therapeutic use; CXC chemokines; Cytokines; direct protein binding; Disease; Drug abuse; Gastric cancer; Humans; Hygiene; IL-17; inflamm-aging; Inflammation; Inflammation - drug therapy; Inflammation - immunology; Inflammation - metabolism; Interleukin 17; Leukocytes (neutrophilic); Life expectancy; Life span; metabolic reprogramming; Neoplasms - drug therapy; Neoplasms - immunology; Neoplasms - metabolism; Neutrophils; oxidative metabolites; Oxidative Stress - drug effects; Preventive medicine; Review; SHMT2; STAT3; Tumor necrosis factor-TNF; Tumors; Vaccination; Wound healing
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20051180

Pleiotropic effects of curcumin have been the subject of intensive research. The interest in this molecule for preventive medicine may further increase because of its potential to modulate inflamm-aging. Although direct data related to its effect on inflamm-aging does not exist, there is a strong possibility that its well-known anti-inflammatory properties may be relevant to this phenomenon. Curcumin's binding to various proteins, which was shown to be dependent on cellular oxidative status, is yet another feature for exploration in depth. Finally, the binding of curcumin to various metabolic enzymes is crucial to curcumin's interference with powerful metabolic machinery, and can also be crucial for metabolic reprogramming of cancer cells. This review offers a synthesis and functional links that may better explain older data, some observational, in light of the most recent findings on curcumin. Our focus is on its modes of action that have the potential to alleviate specific morbidities of the 21st century.