The macular inner plexiform layer thickness as an early diagnostic indicator for Parkinson’s disease

Whether structural alterations of intraretinal layers are indicators for the early diagnosis of Parkinson’s disease (PD) remains unclear. We assessed the retinal layer thickness in different stages of PD and explored whether it can be an early diagnostic indicator for PD. In total, 397 [131, 146, an...

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Published in:NPJ Parkinson's Disease 2022-05, Vol.8 (1), p.63-63, Article 63
Main Authors: Wang, Xin, Jiao, Bin, Jia, Xiaoliang, Wang, Yaqin, Liu, Hui, Zhu, Xiangyu, Hao, Xiaoli, Zhu, Yuan, Xu, Bei, Zhang, Sizhe, Xu, Qian, Wang, Junling, Guo, Jifeng, Yan, Xinxiang, Tang, Beisha, Zhao, Rongchang, Shen, Lu
Format: Article
Language:English
Subjects:
631/378/1689/1718
692/53/2421
692/617/375/346/1718
Age
Behavior disorders
Biomedical and Life Sciences
Biomedicine
Demographics
Dopamine
Eye movements
Generalized linear models
Hospitals
Laboratories
Movement disorders
Neurology
Neurosciences
Parkinson's disease
Questionnaires
Tomography
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Summary:Whether structural alterations of intraretinal layers are indicators for the early diagnosis of Parkinson’s disease (PD) remains unclear. We assessed the retinal layer thickness in different stages of PD and explored whether it can be an early diagnostic indicator for PD. In total, 397 [131, 146, and 120 with Hoehn-Yahr I (H-Y I), H-Y II, and H-Y III stages, respectively] patients with PD and 427 healthy controls (HCs) were enrolled. The peripapillary retinal nerve fiber layer (pRNFL), total macular retinal thickness (MRT), and macular volume (TMV) were measured by high-definition optical coherence tomography, and the macular intraretinal thickness was analyzed by the Iowa Reference Algorithms. As a result, the PD group had a significantly lower average, temporal quadrant pRNFL, MRT, and TMV than the HCs group (all p  
ISSN:2373-8057
2373-8057
DOI:10.1038/s41531-022-00325-8