High-Dose Vitamin D Supplementation Improves Microcirculation and Reduces Inflammation in Diabetic Neuropathy Patients

• Published in: Nutrients 2020-08, Vol.12 (9), p.2518
• Main Authors: Karonova, Tatiana, Stepanova, Anna, Bystrova, Anna, Jude, Edward B
• Format: Article
• Language: English
• Subjects: 25(OH)D; Administration, Oral; Aged; Calciferol; Cholecalciferol - administration & dosage; Cholecalciferol - pharmacology; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Diabetic Neuropathies - diet therapy; Diabetic Neuropathies - drug therapy; Diabetic Neuropathies - metabolism; Diabetic Neuropathies - physiopathology; Diabetic neuropathy; Dietary Supplements; Dose-Response Relationship, Drug; Enzymes; Female; Humans; Immunoassay; Inflammation; Inflammation Mediators - metabolism; inflammatory markers; Interleukin 10; Interleukin 6; Interleukin-10 - metabolism; Interleukin-6 - metabolism; Laboratories; Male; Markers; microcirculation; Microcirculation - drug effects; Middle Aged; neuropathy; Pathogenesis; Patients; Peripheral neuropathy; Signs and symptoms; Skin - blood supply; Tumor necrosis factor-α; Values; Vitamin D; Vitamin deficiency
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12092518

We assessed the effect of different doses of vitamin D supplementation on microcirculation, signs and symptoms of peripheral neuropathy and inflammatory markers in patients with type 2 diabetes (T2DM). Sixty-seven patients with T2DM and peripheral neuropathy (34 females) were randomized into two treatment groups: Cholecalciferol 5000 IU and 40,000 IU once/week orally for 24 weeks. Severity of neuropathy (NSS, NDS scores, visual analogue scale), cutaneous microcirculation (MC) parameters and inflammatory markers (ILs, CRP, TNFα) were assessed before and after treatment. Vitamin D deficiency/insufficiency was detected in 78% of the 62 completed subjects. Following treatment with cholecalciferol 40,000 IU/week, a significant decrease in neuropathy severity (NSS, = 0.001; NDS, = 0.001; VAS, = 0.001) and improvement of cutaneous MC were observed ( < 0.05). Also, we found a decrease in IL-6 level (2.5 pg/mL vs. 0.6 pg/mL, < 0.001) and an increase in IL-10 level (2.5 pg/mL vs. 4.5 pg/mL, < 0.001) after 24 weeks of vitamin D supplementation in this group. No changes were detected in the cholecalciferol 5000 IU/week group. High-dose cholecalciferol supplementation of 40,000 IU/week for 24 weeks was associated with improvement in clinical manifestation, cutaneous microcirculation and inflammatory markers in patients with T2DM and peripheral neuropathy.