Antimicrobial resistance in outpatient Escherichia coli urinary isolates in Dakar, Senegal

• Published in: Journal of infection in developing countries 2007-12, Vol.1 (3), p.263-268
• Main Authors: Sire, Jean-Marie, Nabeth, Pierre, Perrier-Gros-Claude, Jean-David, Bahsoun, Ibrahim, Siby, Tidiane, Macondo, Edgard Adam, Gaye-Diallo, Aïssatou, Guyomard, Stéphanie, Seck, Abdoulaye, Breurec, Sébastien, Garin, Benoit
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Antimicrobial agents; antimicrobial resistance; Bacteriology; Community-Acquired Infections; Community-Acquired Infections - drug therapy; Community-Acquired Infections - epidemiology; Community-Acquired Infections - microbiology; Drug resistance; Drug Resistance, Multiple, Bacterial; E coli; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - isolation & purification; Escherichia coli Infections; Escherichia coli Infections - drug therapy; Escherichia coli Infections - epidemiology; Escherichia coli Infections - microbiology; Female; Humans; Incidence; Life Sciences; Male; Microbial Sensitivity Tests; Microbiology and Parasitology; Middle Aged; outpatient; Outpatients; Penicillin; Pregnancy; Prospective Studies; Senegal; Senegal - epidemiology; urinary tract infection; Urinary Tract Infections; Urinary Tract Infections - drug therapy; Urinary Tract Infections - epidemiology; Urinary Tract Infections - microbiology; Young Adult
• ISSN: 2036-6590; 1972-2680; 1972-2680
• DOI: 10.3855/jidc.362

Data regarding the evolution of antimicrobial resistance are needed to suggest appropriate empirical treatment of urinary tract infections (UTI) in developing countries. To assess the antimicrobial susceptibility of Escherichia coli, the predominant pathogen in community-acquired UTI, a prospective multicenter study was carried out in Dakar, Senegal. From February 2004 to October 2006, 1010 non-duplicate E. coli strains were collected from four centres. Antimicrobial susceptibility testing was performed using disk diffusion method according to the recommendations of the CA-SFM (2004). Most of the isolates were resistant to amoxicillin (73.1%), amoxicillin-clavulanic acid (67.5%), cephalothin (55.8%), and trimethoprim/sulfamethoxazole (68.1%). Extended spectrum beta-lactamase was detected in 38 strains. The overall resistance rates to nalidixic acid, norfloxacin and ciprofloxacin were 23.9%, 16.4% and 15.5%, respectively. Most of the strains were susceptible to gentamicin, nitrofurantoin and fosfomycin (respective susceptibility rates, 93.8%, 89.9%, and 99.3%). During this period, a significant decrease in sensitivity was observed for cephalothin, fluoroquinolones and trimethoprim/sulfamethoxazole (p