The role of inflammatory gene polymorphisms in severe COVID-19: a review

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over the past three years. One critical aspect of the disease is the intricate interplay between the virus and the host immune response, particu...

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Bibliographic Details
Published in:Virology journal 2024-12, Vol.21 (1), p.327-21
Main Authors: Yip, Jia Qi, Oo, Adrian, Ng, Yan Ling, Chin, Kim Ling, Tan, Kim-Kee, Chu, Justin Jang Hann, AbuBakar, Sazaly, Zainal, Nurhafiza
Format: Article
Language:English
Subjects:
Analysis
Anopheles
B cells
Coronaviruses
COVID-19
COVID-19 - genetics
COVID-19 - immunology
COVID-19 - virology
Cytokines - genetics
Gene expression
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genetic research
Health aspects
Humans
Immune response
Inflammation - genetics
Inflammatory gene expression
Polymorphism, Genetic
Review
SARS-CoV-2
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
Severe COVID-19
Severity of Illness Index
Signal Transduction
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Summary:The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over the past three years. One critical aspect of the disease is the intricate interplay between the virus and the host immune response, particularly the role of inflammatory gene expression in severe COVID-19. While numerous previous studies have explored the role of genetic polymorphisms in COVID-19, research specifically focusing on inflammatory genes and their associations with disease severity remains limited. This review explores the relationship between severe COVID-19 outcomes and genetic polymorphisms within key inflammatory genes. By investigating the impact of genetic variations on immune responses, which include cytokine production and downstream signalling pathways, we aim to provide a comprehensive overview of how genetic polymorphisms contribute to the variability in disease presentation. Through an in-depth analysis of existing literature, we shed light on potential therapeutic targets and personalized approaches that may enhance our understanding of disease pathogenesis and treatment strategies.
ISSN:1743-422X
1743-422X
DOI:10.1186/s12985-024-02597-3