Immunohistochemical Analysis of Vimentin in Oral Submucous Fibrosis

Background. Oral submucous fibrosis (OSF), a precancerous condition, is characterized by abnormal accumulation of collagen fibers in oral submucosa. Vimentin is a Class 2 intermediate filament (IF) and primarily expressed in cells of mesenchymal origin. Vimentin is also found to be involved in cell...

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Bibliographic Details
Published in:Journal of Cancer Epidemiology 2013-01, Vol.2013 (2013), p.52-57
Main Authors: Nayak, Meghanand T., Singh, Anjali, Desai, Rajiv S., Vanaki, S. S.
Format: Article
Language:English
Subjects:
Age
Analysis
Antibodies
Care and treatment
Clinical Study
Collagen
Connective tissue
Endothelium
Fibroblasts
Fibrosis
Health aspects
Intermediate filament proteins
Localization
Physiological aspects
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Summary:Background. Oral submucous fibrosis (OSF), a precancerous condition, is characterized by abnormal accumulation of collagen fibers in oral submucosa. Vimentin is a Class 2 intermediate filament (IF) and primarily expressed in cells of mesenchymal origin. Vimentin is also found to be involved in cell growth, cell cycling, and tumour differentiation. Objective. The purpose of the study was to compare the expression of vimentin in various histological grades of OSF. Materials and Methods. To assess the immunohistochemical expression of vimentin in 20 mild cases of OSF, 20 severe cases of OSF, and ten cases of normal oral buccal mucosa. Results. The overall staining intensity of vimentin significantly increased statistically (P
ISSN:1687-8558
1687-8566
DOI:10.1155/2013/549041