E-cadherin on epithelial-mesenchymal transition in thyroid cancer

Thyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets. Epithelial-mesenchymal tra...

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Bibliographic Details
Published in:Cancer cell international 2021-12, Vol.21 (1), p.695-695, Article 695
Main Authors: Zhu, Xiaoyu, Wang, Xiaoping, Gong, Yifei, Deng, Junlin
Format: Article
Language:English
Subjects:
Apoptosis
Cell adhesion & migration
Cytoplasm
E-cadherin
Endocrine system
Genes
Head and neck
Kinases
Lymphatic system
Malignancy
Medical prognosis
Mesenchyme
Metastases
Metastasis
Phosphorylation
Proteins
Review
Signal pathway
Signal transduction
Thyroid cancer
Thyroid carcinoma
Tumors
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Summary:Thyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets. Epithelial-mesenchymal transition (EMT) is associated with tumor malignancy and invasion. One key change in tumour EMT is low expression of E-cadherin. Therefore, this article reviews the expression of E-cadherin in thyroid cancers (TC), discuss the potential mechanisms involved, and outline opportunities to exploit E-cadherin on regulating the occurrence of EMT as a critical factor in cancer therapeutics.
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-021-02344-6