Impact of HPV infection on the development of head and neck cancer

Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is considered to be a distinct clinical entity with better prognosis than the classical tobacco- and alcohol-associated tumors. The increasing incidence of this neoplasia during the last decades highlights the need to b...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 2013-03, Vol.46 (3), p.217-226
Main Authors: Betiol, J, Villa, L L, Sichero, L
Format: Article
Language:English
Subjects:
BIOLOGY
Carcinoma, Squamous Cell - virology
Head and neck cancer
Head and Neck Neoplasms - virology
Human papillomavirus
Humans
MEDICINE, RESEARCH & EXPERIMENTAL
Oncogenic potential
Papillomavirus Infections
Prognosis
Reviews
Risk Factors
Squamous Cell Carcinoma of Head and Neck
Viral prevalence
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Summary:Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is considered to be a distinct clinical entity with better prognosis than the classical tobacco- and alcohol-associated tumors. The increasing incidence of this neoplasia during the last decades highlights the need to better understand the role of HPV in the development of these cancers. Although the proportion of HNSCC attributed to HPV varies considerably according to anatomical site, overall approximately 25% of all HNSCC are HPV-DNA positive, and HPV-16 is by far the most prevalent type. In this review we discuss the existing evidence for a causal association between HPV infection and HNSCC at diverse anatomical head and neck subsites.
ISSN:0100-879X
1414-431X
1414-431X
0100-879X
DOI:10.1590/1414-431X20132703