Circulating Long Noncoding RNA as a Potential Target for Prostate Cancer

Prostate cancer is considered the second most common visceral malignancy in men in Western countries. Its emergence is largely due to the coordination of a malignant network, and long noncoding RNA has been recently demonstrated to play a critical role in prostate carcinogenesis. The aberrant expres...

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Bibliographic Details
Published in:International journal of molecular sciences 2015-06, Vol.16 (6), p.13322-13338
Main Authors: Su, Yin-Jie, Yu, Jin, Huang, Ya-Qin, Yang, Jin
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
biomarker
Biomarkers, Tumor - genetics
Gene Expression Regulation, Neoplastic
Humans
long noncoding RNA
Male
Prognosis
Prostate cancer
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - genetics
Review
Ribonucleic acid
RNA
RNA, Long Noncoding - antagonists & inhibitors
RNA, Long Noncoding - genetics
therapeutic target
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Summary:Prostate cancer is considered the second most common visceral malignancy in men in Western countries. Its emergence is largely due to the coordination of a malignant network, and long noncoding RNA has been recently demonstrated to play a critical role in prostate carcinogenesis. The aberrant expression of long noncoding RNA in prostate cancer patients is strongly associated with diagnosis, risk stratification and carcinogenesis, information that provides new insight into the complicated intracellular milieu of prostate cancer. This review focuses mainly on literature evidence for the role of long noncoding RNA in prostate cancer, which may suggest novel strategies for its prognosis, diagnosis and clinical treatment.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms160613322