Circulation of enterotoxigenic Escherichia coli (ETEC) isolates expressing CS23 from the environment to clinical settings

The importance of clean water cannot be overstated. It is a vital resource for maintaining health and well-being. Unfortunately, water sources contaminated with fecal discharges from animal and human origin due to a lack of wastewater management pose a significant risk to communities, as they can be...

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Bibliographic Details
Published in:mSystems 2023-10, Vol.8 (5), p.e0014123-e0014123
Main Authors: Calderon Toledo, Carla, von Mentzer, Astrid, Agramont, Jorge, Thorell, Kaisa, Zhou, Yingshun, Szabó, Miklós, Colque, Patricia, Kuhn, Inger, Gutiérrez-Cortez, Sergio, Joffré, Enrique
Format: Article
Language:English
Subjects:
bacterial transmission
Bolivia
Diarrhea - epidemiology
Enterotoxigenic Escherichia coli - genetics
Escherichia coli Infections - epidemiology
Escherichia coli Proteins - genetics
ETEC
genomics
human-environment interphase
Humans
infant diarrhea
Medicin och hälsovetenskap
Microbiology in the medical area
Mikrobiologi inom det medicinska området
One Health
PhenePlate
Water
water pollution
waterborne bacteria
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Summary:The importance of clean water cannot be overstated. It is a vital resource for maintaining health and well-being. Unfortunately, water sources contaminated with fecal discharges from animal and human origin due to a lack of wastewater management pose a significant risk to communities, as they can become a means of transmission of pathogenic bacteria like enterotoxigenic (ETEC). ETEC is frequently found in polluted water in countries with a high prevalence of diarrheal diseases, such as Bolivia. This study provides novel insights into the circulation of ETEC between diarrheal cases and polluted water sources in areas with high rates of diarrheal disease. These findings highlight the Choqueyapu River as a potential reservoir for emerging pathogens carrying antibiotic-resistance genes, making it a crucial area for monitoring and intervention. Furthermore, the results demonstrate the feasibility of a low-cost, high-throughput method for tracking bacterial pathogens in low- and middle-income countries, making it a valuable tool for One Health monitoring efforts.
ISSN:2379-5077
2379-5077
DOI:10.1128/msystems.00141-23