Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring

Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of bladder cancer. This review provides a comprehensive overview of the current urine‐based biomarkers and methods for the detection and monitoring of bladder cancer. We focus on biomarkers i...

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Bibliographic Details
Published in:Clinical and translational discovery 2023-04, Vol.3 (2), p.n/a
Main Authors: Zeng, Yuchen, Wang, Anqi, Lv, Wei, Wang, Qingqing, Jiang, Shiqi, Pan, Xiaoguang, Wang, Fei, Yang, Huanming, Bolund, Lars, Lin, Chunhua, Han, Peng, Luo, Yonglun
Format: Article
Language:English
Subjects:
Antigens
Biomarkers
Biopsy
Bladder cancer
Cellular biology
DNA methylation
Hematuria
liquid biopsy
Medical diagnosis
Medical prognosis
MicroRNAs
Proteins
Surveillance
Urine
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Summary:Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of bladder cancer. This review provides a comprehensive overview of the current urine‐based biomarkers and methods for the detection and monitoring of bladder cancer. We focus on biomarkers including tumour DNAs, proteins, microbiome, tumour RNAs, long non‐coding RNAs, transfer RNA‐derived fragments, messenger RNAs, microRNAs, circular RNAs, exosomes and extrachromosomal circular DNA. A systematic overview of technical considerations in developping urine biomarkers. Seven classes of urine biomarkers are summarised for bladder cancer detection and monitoring. Highlight of limitations and future improvements.
ISSN:2768-0622
2768-0622
DOI:10.1002/ctd2.183