Using blood cytokine measures to define high inflammatory biotype of schizophrenia and schizoaffective disorder

Increases in pro-inflammatory cytokines are found in the brain and blood of people with schizophrenia. However, increased cytokines are not evident in all people with schizophrenia, but are found in a subset. The cytokine changes that best define this subset, termed the "elevated inflammatory b...

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Bibliographic Details
Published in:Journal of neuroinflammation 2017-09, Vol.14 (1), p.188-188, Article 188
Main Authors: Boerrigter, Danny, Weickert, Thomas W, Lenroot, Rhoshel, O'Donnell, Maryanne, Galletly, Cherrie, Liu, Dennis, Burgess, Martin, Cadiz, Roxanne, Jacomb, Isabella, Catts, Vibeke S, Fillman, Stu G, Weickert, Cynthia Shannon
Format: Article
Language:English
Subjects:
Adult
Analysis
Biomarkers - blood
Biotype
Biotypes
Blood
Blood platelets
Clinical trials
Cytokines
Cytokines - blood
Development and progression
Diagnosis
Female
Gene expression
Genetic aspects
Genomics
Humans
Immune system
Inflammation
Inflammation - blood
Interleukin 10
Interleukin 12
Interleukin 18
Interleukin 2
Interleukin 6
Interleukin 8
Male
Mental depression
Mental disorders
Meta-analysis
Middle Aged
Peripheral blood
Periphery
Physiological aspects
Plasma
Plasma levels
Polymerase chain reaction
Proteins
Psychiatry
Psychotic Disorders - blood
Psychotropic drugs
Schizoaffective disorder
Schizophrenia
Schizophrenia - blood
Studies
Transcription
Tumor necrosis factor-TNF
Young Adult
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Summary:Increases in pro-inflammatory cytokines are found in the brain and blood of people with schizophrenia. However, increased cytokines are not evident in all people with schizophrenia, but are found in a subset. The cytokine changes that best define this subset, termed the "elevated inflammatory biotype", are still being identified. Using quantitative RT-PCR, we measured five cytokine mRNAs (IL-1β, IL-2 IL-6, IL-8 and IL-18) from peripheral blood of healthy controls and of people with schizophrenia or schizoaffective disorder (n = 165). We used a cluster analysis of the transcript levels to define those with low and those with elevated levels of cytokine expression. From the same cohort, eight cytokine proteins (IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12, IFNγ and TNFα) were measured in serum and plasma using a Luminex Magpix-based assay. We compared peripheral mRNA and protein levels across diagnostic groups and between those with low and elevated levels of cytokine expression according to our transcription-based cluster analysis. We found an overall decrease in the anti-inflammatory IL-2 mRNA (p = 0.006) and an increase in three serum cytokines, IL-6 (p = 0.010), IL-8 (p = 0.024) and TNFα (p 
ISSN:1742-2094
1742-2094
DOI:10.1186/s12974-017-0962-y