Mechanisms of Autoantibody-Induced Pathology

Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves' disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease....

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2017-05, Vol.8, p.603-603
Main Authors: Ludwig, Ralf J, Vanhoorelbeke, Karen, Leypoldt, Frank, Kaya, Ziya, Bieber, Katja, McLachlan, Sandra M, Komorowski, Lars, Luo, Jie, Cabral-Marques, Otavio, Hammers, Christoph M, Lindstrom, Jon M, Lamprecht, Peter, Fischer, Andrea, Riemekasten, Gabriela, Tersteeg, Claudia, Sondermann, Peter, Rapoport, Basil, Wandinger, Klaus-Peter, Probst, Christian, El Beidaq, Asmaa, Schmidt, Enno, Verkman, Alan, Manz, Rudolf A, Nimmerjahn, Falk
Format: Article
Language:English
Subjects:
autoantibodies
autoimmunity
B cells
Immunology
mouse models
pathogenesis
treatment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves' disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease. Pathways leading to autoantibody-induced pathology greatly differ among different diseases, and autoantibodies directed against the same antigen, depending on the targeted epitope, can have diverse effects. To foster knowledge in autoantibody-induced pathology and to encourage development of urgently needed novel therapeutic strategies, we here categorized autoantibodies according to their effects. According to our algorithm, autoantibodies can be classified into the following categories: (1) mimic receptor stimulation, (2) blocking of neural transmission, (3) induction of altered signaling, triggering uncontrolled (4) microthrombosis, (5) cell lysis, (6) neutrophil activation, and (7) induction of inflammation. These mechanisms in relation to disease, as well as principles of autoantibody generation and detection, are reviewed herein.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2017.00603