The trajectory of osteoblast progenitor cells in patients with type 2 diabetes and the predictive model for their osteogenic differentiation ability

The fate of osteoprogenitor cells along with the progression of type 2 diabetes (T2DM) and factors determining the fate of those cells remains to be elucidated. This cross-sectional study included 18 normoglycemic, 27 prediabetic, and 73 T2DM to determine osteogenic differentiation across the contin...

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Bibliographic Details
Published in:Scientific reports 2023-02, Vol.13 (1), p.2338-2338, Article 2338
Main Authors: Phimphilai, Mattabhorn, Pothacharoen, Peraphan, Chattipakorn, Nipon, Kongtawelert, Prachya
Format: Article
Language:English
Subjects:
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Cell Differentiation
Cross-Sectional Studies
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Glomerular filtration rate
Humanities and Social Sciences
Humans
Leukocytes, Mononuclear
multidisciplinary
Osteoblasts
Osteogenesis
Osteoprogenitor cells
Peripheral blood mononuclear cells
Prediabetic State
Prediction models
Progenitor cells
Risk factors
Science
Science (multidisciplinary)
Stem Cells
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Summary:The fate of osteoprogenitor cells along with the progression of type 2 diabetes (T2DM) and factors determining the fate of those cells remains to be elucidated. This cross-sectional study included 18 normoglycemic, 27 prediabetic, and 73 T2DM to determine osteogenic differentiation across the continuum of dysglycemia and to construct a model to predict the fate of osteoprogenitor cells. This study demonstrated a preserved osteogenic differentiation ability of peripheral blood-derived mononuclear cells (PBMC) isolated from normoglycemic and prediabetic but a progressive decline in their osteogenic differentiation during the progression of T2DM. The rate of osteogenic differentiation rapidly declined by 4–7% annually during the first 10 years of diabetes and then slowed down. A predictive model composed of three independent risk factors, including age, duration of diabetes, and glomerular filtration rate, demonstrated an AuROC of 0.834. With a proposed cut-off of 21.25, this model had 72.0% sensitivity, 87.5% specificity, and 78.9% accuracy in predicting the fate of osteoprogenitor cells. In conclusion, this study provided a perspective on the osteogenic differentiation ability of the osteoprogenitor cells across a continuum of dysglycemia and a predictive model with good diagnostic performance for the prediction of the fate of osteoprogenitor cells in patients with T2DM.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-29677-8