A comparison between the effects of Portulaca oleracea seeds extract and valsartan on echocardiographic and hemodynamic parameters in rats with levothyroxine-induced thyrotoxicosis

The aim of the present study was to compare the effects of (Po) seeds extract and those of valsartan on cardiac function in levothyroxine (T )-treated rats. Forty Wistar rats were divided into four groups (n=10): control, levothyroxine (T ), T plus valsartan (T -Val) and T plus hydro-alcoholic extra...

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Bibliographic Details
Published in:Avicenna journal of phytomedicine 2018-05, Vol.8 (3), p.276-285
Main Authors: Pakdel, Roghayeh, Niazmand, Saeed, Mouhebati, Mohsen, Vahedi, Mohammad Mahdi, Aghaee, Azita, Hadjzadeh, Mousa-Al-Reza
Format: Article
Language:English
Subjects:
echocardiography
Hemodynamic parameters
Hyperthyroidism
Levothyroxine
Original
Portulaca oleracea
Valsartan
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Summary:The aim of the present study was to compare the effects of (Po) seeds extract and those of valsartan on cardiac function in levothyroxine (T )-treated rats. Forty Wistar rats were divided into four groups (n=10): control, levothyroxine (T ), T plus valsartan (T -Val) and T plus hydro-alcoholic extract of the seeds (T -Po). Control group received normal saline. Levothyroxine (100µg/kg/day, i.p.) was administered to three other groups for 4 weeks. Valsartan (8 mg/kg/day, orally) and Po seeds extract (400 mg/kg/day, orally) were administered during the last two weeks of treatment period. At the end of the experiment, echocardiographic and hemodynamic parameters were measured and serum free T , T , and T were measured. Administration of T for 4 weeks significantly increased serum free T levels in T group but elevations of free T levels in T -Val group were not significant. Free T level decreased in T -Po (p
ISSN:2228-7930
2228-7949
DOI:10.22038/ajp.2018.10274