Biochemical, immunological markers, histology and ultrastructural changes of open wound healing in rats treated with ethyl acetate extract of Zingiber zerumbet rhizomes

Research on plant-based wound healing agents has been one of the current developing areas in modern biomedical science. This study aimed to assess the effects of ethyl acetate extract of Zingiber zerumbet rhizome (ZZRE) on open wound healing activity in Wistar rats. Ninety male Wistar rats (220–320 ...

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Bibliographic Details
Published in:Heliyon 2024-10, Vol.10 (20), p.e39339, Article e39339
Main Authors: Hamid, Asmah, Chong, Pek Lian, Khor, Yun Ying, Kong, Poh Ying, Rasli, Nur Rasyiqin, Abd Warif, Nor Malia, Ghazali, Ahmad Rohi, Jufri, Nurul Farhana
Format: Article
Language:English
Subjects:
Biochemical markers
Ethyl acetate
Ultrastructure
Wound healing
Z. zerumbet
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Summary:Research on plant-based wound healing agents has been one of the current developing areas in modern biomedical science. This study aimed to assess the effects of ethyl acetate extract of Zingiber zerumbet rhizome (ZZRE) on open wound healing activity in Wistar rats. Ninety male Wistar rats (220–320 g) were divided into three groups treated with phosphate buffered saline (PBS) (negative control), Solcoseryl gel (positive control), and 10 % ZZRE (treatment group), respectively. Six circular full-skin thickness wounds of 6.0 mm in diameter were induced bilaterally on the dorsal surface of each rat. Six rats were sacrificed on Day-1, Day-3, Day-6, Day-10 and Day-14 respectively from each group after wound induction. All data obtained are considered statistically significant at p 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e39339