Multi-Target Potential of Berberine as an Antineoplastic and Antimetastatic Agent: A Special Focus on Lung Cancer Treatment

Despite therapeutic advancements, lung cancer remains the principal cause of cancer mortality in a global scenario. The increased incidence of tumor reoccurrence and progression and the highly metastatic nature of lung cancer are of great concern and hence require the investigation of novel therapie...

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Published in:Cells (Basel, Switzerland) Switzerland), 2022-10, Vol.11 (21), p.3433
Main Authors: Achi, Ijeoma Theresa, Sarbadhikary, Paromita, George, Blassan P, Abrahamse, Heidi
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
Autophagy
Berberine
Berberine - chemistry
Berberine - pharmacology
Berberine - therapeutic use
Cancer therapies
Care and treatment
Cell cycle
Cell death
Cell growth
Cell Proliferation
Cell viability
Humans
Kinases
Lung cancer
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Metastases
miRNA
Mortality
phytochemicals
Review
signaling pathways
Telomerase
Testicular cancer
Testing
Tumor Microenvironment
Tumors
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Summary:Despite therapeutic advancements, lung cancer remains the principal cause of cancer mortality in a global scenario. The increased incidence of tumor reoccurrence and progression and the highly metastatic nature of lung cancer are of great concern and hence require the investigation of novel therapies and/or medications. Naturally occurring compounds from plants serve as important resources for novel drugs for cancer therapy. Amongst these phytochemicals, Berberine, an alkaloid, has been extensively explored as a potential natural anticancer therapeutic agent. Several studies have shown the effectiveness of Berberine in inhibiting cancer growth and progression mediated via several different mechanisms, which include cell cycle arrest, inducing cell death by apoptosis and autophagy, inhibiting cell proliferation and invasion, as well as regulating the expression of microRNA, telomerase activity, and the tumor microenvironment, which usually varies for different cancer types. In this review, we aim to provide a better understanding of molecular insights of Berberine and its various derivative-induced antiproliferative and antimetastatic effects against lung cancer. In conclusion, the Berberine imparts its anticancer efficacy against lung cancers via modulation of several signaling pathways involved in cancer cell viability and proliferation, as well as migration, invasion, and metastasis.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11213433