Infant Milk Formula Enriched in Dairy Cream Brings Its Digestibility Closer to Human Milk and Supports Intestinal Health in Pre-Clinical Studies

Human breast milk (HBM) is the "gold standard" for infant nutrition. When breast milk is insufficient or unavailable, infant milk formula (IMF) can provide a safe and nutritious alternative. However, IMFs differ considerably from HBM in composition and health function. We compared the dige...

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Bibliographic Details
Published in:Nutrients 2024-09, Vol.16 (18), p.3065
Main Authors: Kondrashina, Alina, Mamone, Gianfranco, Giblin, Linda, Lane, Jonathan A
Format: Article
Language:English
Subjects:
Amino acids
Animals
Babies
Breast feeding
Breastfeeding & lactation
Caco-2 Cells
Caenorhabditis elegans
Carbohydrates
Clinical trials
cream
dairy lipids
Dairy Products
Digestion
Fatty acids
HT29 Cells
Humans
Infant
infant formula
Infant Formula - chemistry
infant nutrition
Infant Nutritional Physiological Phenomena
Infants
International economic relations
Intestines - physiology
Lipids
Medical research
Medicine, Experimental
Microbiota
Milk
milk fat globule
Milk, Human - chemistry
Nutrients
Oils & fats
Peptides
Pharmaceutical industry
Proteins
Triglycerides
Vegetable oils
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Summary:Human breast milk (HBM) is the "gold standard" for infant nutrition. When breast milk is insufficient or unavailable, infant milk formula (IMF) can provide a safe and nutritious alternative. However, IMFs differ considerably from HBM in composition and health function. We compared the digestibility and potential health functions of IMF containing low cream (LC-) or high cream (HC-) with pooled HBM. After simulated infant digestion of these samples, the bioavailability of key nutrients and immunomodulatory activities were determined via cell-based assays. A leaky gut model was established to investigate cream effects on gut health. Distinct differences were observed in peptide diversity and sequences released from HC-IMF compared with LC-IMF during simulated digestion ( < 0.05). Higher levels of free fatty acids were absorbed through 21-day differentiated Caco-2/HT-29MTX monolayers from HC-IMF, compared with LC-IMF and HBM ( < 0.05). Furthermore, the immune-modulating properties of HC-IMF appeared to be more similar to HBM than LC-IMF, as observed by comparable secretion of cytokines IL-10 and IL-1β from THP-1 macrophages ( > 0.05). HC-IMF also supported intestinal recovery in following distortion versus LC-IMF ( < 0.05). These observations suggest that cream as a lipid source in IMF may provide added nutritional and functional benefits more aligned with HBM.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16183065