Endothelial Cells and Mitochondria: Two Key Players in Liver Transplantation

Building the inner layer of our blood vessels, the endothelium forms an important line communicating with deeper parenchymal cells in our organs. Previously considered passive, endothelial cells are increasingly recognized as key players in intercellular crosstalk, vascular homeostasis, and blood fl...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-06, Vol.24 (12), p.10091
Main Authors: Parente, Alessandro, Flores Carvalho, Mauricio, Schlegel, Andrea
Format: Article
Language:English
Subjects:
Blood vessels
Communication
Cytokines
Endothelial cells
Endothelial Cells - metabolism
Endothelium
Fatty acids
Fluidity
Growth factors
Hepatocytes
Hepatocytes - metabolism
Homeostasis
Hypoxia
Ischemia
ischemia-reperfusion injury
Liver
Liver - metabolism
Liver Transplantation
Liver transplants
machine perfusion
Metabolism
Metabolites
Mitochondria
Mitochondrial DNA
Organ Preservation
Oxidation
Oxygenation
Perfusion
Physiology
Players
reactive oxygen species
Respiration
Review
Shear stress
shears stress
Sine waves
Transplantation
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Summary:Building the inner layer of our blood vessels, the endothelium forms an important line communicating with deeper parenchymal cells in our organs. Previously considered passive, endothelial cells are increasingly recognized as key players in intercellular crosstalk, vascular homeostasis, and blood fluidity. Comparable to other cells, their metabolic function strongly depends on mitochondrial health, and the response to flow changes observed in endothelial cells is linked to their mitochondrial metabolism. Despite the direct impact of new dynamic preservation concepts in organ transplantation, the impact of different perfusion conditions on sinusoidal endothelial cells is not yet explored well enough. This article therefore describes the key role of liver sinusoidal endothelial cells (LSECs) together with their mitochondrial function in the context of liver transplantation. The currently available ex situ machine perfusion strategies are described with their effect on LSEC health. Specific perfusion conditions, including perfusion pressure, duration, and perfusate oxygenation are critically discussed considering the metabolic function and integrity of liver endothelial cells and their mitochondria.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241210091