Disrupt of Intra-Limb APA Pattern in Parkinsonian Patients Performing Index-Finger Flexion

• Published in: Frontiers in physiology 2018-12, Vol.9, p.1745-1745
• Main Authors: Bolzoni, Francesco, Esposti, Roberto, Marchese, Silvia M, Pozzi, Nicoló G, Ramirez-Pasos, Uri E, Isaias, Ioannis U, Cavallari, Paolo
• Format: Article
• Language: English
• Subjects: basal ganglia; human; intra-limb anticipatory postural adjustments; motor control; Parkinson disease; Physiology
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2018.01745

Voluntary movements induce postural perturbations which are counteracted by anticipatory postural adjustments (APAs). These actions are known to build up long fixation chains toward available support points ( APAs), so as to grant whole body equilibrium. Moreover, recent studies highlighted that APAs also build-up short fixation chains, within the same limb where a distal segment is moved ( APAs), aimed at stabilizing the proximal segments. The neural structures generating intra-limb APAs still need investigations; the present study aims to compare focal movement kinematics and intra-limb APA latencies and pattern between healthy subjects and parkinsonian patients, assuming the latter as a model of basal ganglia dysfunction. Intra-limb APAs that stabilize the arm when the index-finger is briskly flexed were recorded in 13 parkinsonian patients and in 10 age-matched healthy subjects. Index-finger movement was smaller in parkinsonian patients vs. healthy subjects ( = 0.01) and more delayed with respect to the onset of the prime mover flexor digitorum superficialis (FDS, < 0.0001). In agreement with the literature, in all healthy subjects the FDS activation was preceded by an inhibitory intra-limb APA in biceps brachii (BB) and anterior deltoid (AD), and almost simultaneous to an excitatory intra-limb APA in triceps brachii (TB). In parkinsonian patients, no significant differences were found for TB and AD intra-limb APA timings, however only four patients showed an inhibitory intra-limb APA in BB, while other four did not show any BB intra-limb APAs and five actually developed a BB excitation. The frequency of occurrence of , , and BB APAs was different in healthy vs. parkinsonian participants ( = 0.0016). The observed alterations in index-finger kinematics and intra-limb APA pattern in parkinsonian patients suggest that basal ganglia, in addition to shaping the focal movement, may also contribute to intra-limb APA control.