Alterations in the gut microbiome and metabolome profiles of septic rats treated with aminophylline

The treatment of sepsis remains a major challenge worldwide. Aminophylline has been shown to have anti-inflammatory effects; however, the role of aminophylline in sepsis, a disease characterized by immune dysregulation, is unknown. In this study, we combined microbiome sequencing and metabolomic ass...

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Bibliographic Details
Published in:Journal of translational medicine 2022-02, Vol.20 (1), p.69-69, Article 69
Main Authors: Li, Yuanzhe, Zhao, Huayan, Sun, Guiying, Duan, Yongtao, Guo, Yanjun, Xie, Lina, Ding, Xianfei
Format: Article
Language:English
Subjects:
Abdomen
Adenosine
Aminophylline
Analysis
Annotations
Bacteria
Care and treatment
Chenodeoxycholic acid
Cytokines
Data analysis
Diagnosis
Digestive system
Dosage and administration
Escherichia
Health aspects
Inflammation
Intestinal microflora
Intestine
Lactobacillus
Mass spectrometry
Medical prognosis
Metabolites
Metabolomics
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Mortality
Pathogenesis
Physiological aspects
Scientific imaging
Sepsis
Shigella
Software
Sutures
Taxonomy
Testing
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Summary:The treatment of sepsis remains a major challenge worldwide. Aminophylline has been shown to have anti-inflammatory effects; however, the role of aminophylline in sepsis, a disease characterized by immune dysregulation, is unknown. In this study, we combined microbiome sequencing and metabolomic assays to investigate the effect of aminophylline administration on the intestinal flora and metabolites in septic rats. Sixty SD rats were randomly divided into three groups: a sham-operated (SC) group, a sepsis model (CLP) group and a CLP + aminophylline treatment (Amino) group. The intestinal flora and metabolic profile of rats in the CLP group were significantly different than those of the SC group, while aminophylline administration resulted in a return to a state similar to healthy rats. Differential abundance analysis showed that aminophylline significantly back-regulated the abundance of Firmicutes, unidentified_Bacteria, Proteobacteria, Lactobacillus, Escherichia-Shigella and other dominant bacteria (P  1, P 
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-022-03280-3