What is the role of adipokines in myasthenia gravis?

Myasthenia gravis (MG) is a disease with autoimmune etiology. The main pathomechanism is related to the production of antibodies against nicotinic acetylcholine receptor. The present study is aimed to compare the serum level of adipokines in patients with MG with that in controls, as well as to stud...

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Bibliographic Details
Published in:Therapeutics and clinical risk management 2018-01, Vol.14, p.1515-1525
Main Authors: Rozmilowska, Izabela, Czyzewski, Damian, Mazur, Bogdan, Adamczyk-Sowa, Monika
Format: Article
Language:English
Subjects:
Adipocytes
adiponectin
Antibodies
Autoimmune diseases
B cells
Cytokines
Development and progression
Disease
Etiology (Medicine)
Immunoglobulins
Inflammation
Leptin
Lupus
Lymphocytes
Meta-analysis
Metabolic disorders
Metabolic syndrome
Myasthenia gravis
Nervous system
omentin
Original Research
resistin
Rheumatoid arthritis
Systematic review
Thoracic surgery
Tumor necrosis factor-TNF
visfatin
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Summary:Myasthenia gravis (MG) is a disease with autoimmune etiology. The main pathomechanism is related to the production of antibodies against nicotinic acetylcholine receptor. The present study is aimed to compare the serum level of adipokines in patients with MG with that in controls, as well as to study the relation of these levels with disease severity. Fifty patients with MG and 30 healthy individuals were enrolled in our study. Serum concentrations of select adipokines, namely adiponectin, leptin, omentin, visfatin, and resistin were measured. The results showed a significant increase in serum concentrations of adiponectin and resistin in the patients with MG compared with the controls. Further studies are warranted to assess changes in adipokine concentration levels in patients with MG.
ISSN:1176-6336
1178-203X
1178-203X
DOI:10.2147/TCRM.S163966