Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by...

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Bibliographic Details
Published in:Parasites & vectors 2022-03, Vol.15 (1), p.112-31, Article 112
Main Authors: Ratcliffe, Norman A, Furtado Pacheco, João P, Dyson, Paul, Castro, Helena Carla, Gonzalez, Marcelo S, Azambuja, Patricia, Mello, Cicero B
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified
Aquatic insects
Chemical pest control
Control
Control methods
Culicidae
Culture techniques
Disease transmission
Drug resistance
Environmental release
Genetic engineering
Genetic modification
Genetically engineered organisms
Genetically modified organisms
Insect vectors
Insect Vectors - genetics
Insecticide resistance
Insects
Insects as carriers of disease
Methods
Microbiome
Microorganisms
Mosquito Vectors
Mosquitoes
Parasites
Parasitic diseases
Paratrangenesis
Pathogens
Pest control
Pesticides
Review
Triatomines
Tsetse flies
Tsetse Flies - microbiology
Vector control
Vectors
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Summary:This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly ingenious method currently under development in many important vector insects that could provide an additional powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis technique are detailed and an overview is given of the microorganisms selected for genetic modification, the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes, sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental release of the genetically engineered organisms produced in paratransgenesis are considered.
ISSN:1756-3305
1756-3305
DOI:10.1186/s13071-021-05132-3