Kikuchi-Fujimoto disease in children: two case reports and a review of the literature

Kikuchi-Fujimoto disease is a rare, idiopathic and generally self-limiting cause of lymphadenitis of unknow etiology with a low recurrence rate. The typical clinical signs are cervical lymphadenopathy, fever, and symptoms of respiratory infection, and less frequently chills, night sweats, arthralgia...

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Bibliographic Details
Published in:Italian journal of pediatrics 2018-07, Vol.44 (1), p.83-83, Article 83
Main Authors: Lelii, Mara, Senatore, Laura, Amodeo, Ilaria, Pinzani, Raffaella, Torretta, Sara, Fiori, Stefano, Marchisio, Paola, Bosis, Samantha
Format: Article
Language:English
Subjects:
Abdomen
Adolescent
Arthralgia
Arthritis
Biopsy
Blood tests
Case Report
Case reports
Child
Children
Cytomegalovirus
Differential diagnosis
Disease
Enzymes
Etiology
Female
Fever
Hemophagocytic lymphohistiocytosis
Histiocytic Necrotizing Lymphadenitis - complications
Histiocytic Necrotizing Lymphadenitis - diagnosis
Histiocytic Necrotizing Lymphadenitis - therapy
Humans
Infections
Kikuchi-Fujimoto disease
Laboratories
Literature reviews
Lymphadenitis
Lymphadenopathy
Lymphatic diseases
Lymphatic system
Lymphoma
Male
Neck
Pediatrics
Persistent fever
Recurrent lymphadenitis
Relapsing Kikuchi-Fujimoto disease
Urine
Viral infections
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Description
Summary:Kikuchi-Fujimoto disease is a rare, idiopathic and generally self-limiting cause of lymphadenitis of unknow etiology with a low recurrence rate. The typical clinical signs are cervical lymphadenopathy, fever, and symptoms of respiratory infection, and less frequently chills, night sweats, arthralgia, rash, and weight loss. Here we describe two case reports of Kikuchi Fujimoto disease presenting in Milan within the space of a few months. The first involved the recurrence of KFD in a young boy from Sri Lanka; the second was a rare case of severe KFD complicated by HLH. Pediatricians must consider KFD in the differential diagnosis of fever of unknown origin in children, even in western countries. Although rare, recurrence and severe complications are possible. Where symptoms suggest KFD, a systematic diagnostic approach is key. Since no guidelines on the management of KFD are available, further studies should be conducted to investigate the therapeutic options and long term outcome in children.
ISSN:1824-7288
1720-8424
1824-7288
DOI:10.1186/s13052-018-0522-9