Optic nerve head neurovascular assessments in patients with schizophrenia: A cross‐sectional study

Objective The retina is a protrusion of the brain, so researchers have recently proposed retinal changes as a new marker for studying central nervous system diseases. To investigate optic nerve head neurovascular structure assessed by optical coherence tomography angiography (OCTA) in schizophrenia...

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Bibliographic Details
Published in:Health science reports 2024-05, Vol.7 (5), p.e2100-n/a
Main Authors: Daneshvar, Ramin, Naghib, Maryam, Fayyazi Bordbar, Mohammad Reza, Faridhosseini, Farhad, Fotouhi, Marziyeh, Motamed Shariati, Mehrdad
Format: Article
Language:English
Subjects:
Alzheimer's disease
Chronic illnesses
Cross-sectional studies
Disease
Glaucoma
Hypertension
illness severity
Independent sample
Intracranial pressure
optic disc
Optic nerve
optical coherence tomography angiography
optical imaging
Original Research
Psychopathology
Schizophrenia
Software
Statistical analysis
Tomography
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Summary:Objective The retina is a protrusion of the brain, so researchers have recently proposed retinal changes as a new marker for studying central nervous system diseases. To investigate optic nerve head neurovascular structure assessed by optical coherence tomography angiography (OCTA) in schizophrenia compared to healthy subjects. Methods The study was conducted from 2019 to 2021 at the Ibn Sina Psychiatric Hospital in Mashhad, Iran. We enrolled 22 hospitalized known cases of schizophrenia, treated with risperidone as an antipsychotic drug, and 22 healthy subjects. The two groups were matched in age and gender. In the schizophrenic group, the positive and negative syndrome scale test was used to assess the illness severity. All subjects underwent complete ophthalmic evaluations and OCTA imaging. Results We found that the cup/disc area ratio, vertical cup/disc ratio, and horizontal cup/disc ratio are significantly higher in patients with schizophrenia than in healthy subjects (with p‐values of 0.019, 0.015, and 0.022, respectively). No statistically significant difference in the peripapillary retinal nerve fiber layer and vascular parameters of the optic nerve head was observed between schizophrenia and healthy groups. Conclusion We found evidence regarding the difference in the optic nerve head tomographic properties in schizophrenia compared to healthy subjects. However, ONH vascular parameters showed no significant difference. More studies are needed for a definite conclusion.
ISSN:2398-8835
2398-8835
DOI:10.1002/hsr2.2100