Psoriasis vulgaris occurring in a known case of neurofibromatosis type I: A rare association

Neurofibromatosis type 1 (NF-1) is an autosomal dominantly inherited neurocutaneous disorder due to mutations in the neurofibromin (NF) gene that encodes protein NF. NF regulates signal transduction by inactivating RAS proteins. Mutations in the NF-1 gene increases RAS activity causing increased tra...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Dr. NTR university of health sciences 2016-07, Vol.5 (3), p.238-240
Main Authors: Chalam, Konakanchi, Kumar, Gummalla, Yandapalli, Padmasri, Sunandini, Anila
Format: Article
Language:English
Subjects:
Case studies
Genetic aspects
Neurofibromatosis
Neurofibromatosis type 1 (NF-1)
neurofibromin (NF) gene
Psoriasis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurofibromatosis type 1 (NF-1) is an autosomal dominantly inherited neurocutaneous disorder due to mutations in the neurofibromin (NF) gene that encodes protein NF. NF regulates signal transduction by inactivating RAS proteins. Mutations in the NF-1 gene increases RAS activity causing increased transduction of many growth factors and kinase pathways leading to increased mitosis and occurrence of neoplasms and proliferative conditions such as psoriasis. Psoriasis is a chronic, inflammatory proliferative condition of the skin in which both genetic and environmental factors have a vital role. The underlying pathogenesis is epidermal proliferation, vascular changes, and inflammatory changes mediated by multiple growth factors of which in particular are epidermal growth factor (EGF), transforming growth factor (TGF)-alpha, tumor necrosis factor (TNF)-alpha etc. We report a rare association of NF-1 with psoriasis occurring by chance or due to decreased NF protein.
ISSN:2277-8632
2277-8632
DOI:10.4103/2277-8632.191838