STING Signaling Promotes Apoptosis, Necrosis, and Cell Death: An Overview and Update

STING is a newly identified intracellular sensor of foreign and endogenous DNA. STING has been recognized as an activator of immune responses by TBK1/IRF3 and NF-κB pathways, and it is suggested to play critical roles in host defense, autoimmune diseases, and tumor immunity. Recent studies have reve...

Full description

Saved in:
Bibliographic Details
Published in:Mediators of inflammation 2018-01, Vol.2018 (2018), p.1-4
Main Authors: Liu, Song, Guan, Wenxian
Format: Article
Language:English
Subjects:
Animals
Antigens
Apoptosis
Apoptosis - genetics
Apoptosis - physiology
Autoimmune diseases
B cells
Biochemistry
Cancer
Cell activation
Cell death
Cell Death - genetics
Cell Death - physiology
Cell growth
Cooperation
Cytotoxicity
Dendritic cells
Deoxyribonucleic acid
DNA
Gangrene
Gene expression
Homeostasis
Humans
Immune response
Inflammation
Interferon
Interferon regulatory factor 3
Leukemia
Liver diseases
Lymphocytes
Membrane Proteins - genetics
Membrane Proteins - metabolism
Mitochondrial DNA
Nanoparticles
Necrosis
Necrosis - metabolism
NF-κB protein
Review
Signal Transduction - genetics
Signal Transduction - physiology
Tumor necrosis factor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:STING is a newly identified intracellular sensor of foreign and endogenous DNA. STING has been recognized as an activator of immune responses by TBK1/IRF3 and NF-κB pathways, and it is suggested to play critical roles in host defense, autoimmune diseases, and tumor immunity. Recent studies have revealed that the outcome of STING activation could vary between distinct cell types and scenarios. STING activation in certain cell types triggered cell death including apoptosis and necrosis. This effect could be critical for preventing unnecessary or excessive inflammatory events and maintaining host immune homeostasis. This review is dedicated to summarize recent evidences in the field of STING-mediated cell death and to demonstrate dual outcomes of STING signaling. Besides canonical immune responses represented by IFN and TNF productions, STING signaling can also induce cell death events in a variety of cell types. The double-faced characteristics of STING signaling requires further exploration and precious regulation before tailoring clinical strategies for associated diseases.
ISSN:0962-9351
1466-1861
DOI:10.1155/2018/1202797