In Vitro Antibacterial Activity of Microbial Natural Products against Bacterial Pathogens of Veterinary and Zoonotic Relevance

Antimicrobial resistance (AMR) is considered one of the greatest threats to both human and animal health. Efforts to address AMR include implementing antimicrobial stewardship programs and introducing alternative treatment options. Nevertheless, effective treatment of infectious diseases caused by b...

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Bibliographic Details
Published in:Antibiotics (Basel) 2024-02, Vol.13 (2), p.135
Main Authors: Barth, Stefanie A, Preussger, Daniel, Pietschmann, Jana, Feßler, Andrea T, Heller, Martin, Herbst, Werner, Schnee, Christiane, Schwarz, Stefan, Kloss, Florian, Berens, Christian, Menge, Christian
Format: Article
Language:English
Subjects:
Acids
Animal health
Antibacterial activity
Antibiotics
Antimicrobial activity
Antimicrobial agents
Antimicrobial resistance
antimicrobial susceptibility testing
Bacteria
Brachyspira
Chlamydia abortus
Clostridioides difficile
Gram-positive bacteria
Infectious diseases
Mannheimia haemolytica
Microorganisms
Mycobacterium
Mycoplasma
Natural products
Pasteurella
Pasteurella multocida
Pathogens
Pharmacology
Phenotypes
Sexually transmitted diseases
STD
Veterinary medicine
Zoonoses
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Summary:Antimicrobial resistance (AMR) is considered one of the greatest threats to both human and animal health. Efforts to address AMR include implementing antimicrobial stewardship programs and introducing alternative treatment options. Nevertheless, effective treatment of infectious diseases caused by bacteria will still require the identification and development of new antimicrobial agents. Eight different natural products were tested for antimicrobial activity against seven pathogenic bacterial species ( sp., sp., sp., sp., sp., sp., sp.). In a first pre-screening, most compounds (five out of eight) inhibited bacterial growth only at high concentrations, but three natural products (celastramycin A [CA], closthioamide [CT], maduranic acid [MA]) displayed activity at concentrations 16 µg/mL against for CA, CT, and MA, respectively. CA, CT, and MA exhibited higher MIC and MIC values against isolates with a known AMR phenotype against commonly used therapeutic antimicrobial agents than against isolates with unknown AMR profiles. This study demonstrates the importance of whole-cell antibacterial screening of natural products to identify promising scaffolds with broad- or narrow-spectrum antimicrobial activity against important Gram-negative veterinary pathogens with zoonotic potential.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics13020135