Accuracy of Urine Kidney Injury Molecule-1 in Predicting Acute Kidney Injury in Children; a Systematic Review and Meta-Analysis

• Published in: Archives of academic emergency medicine 2020-01, Vol.8 (1), p.e44-e44
• Main Authors: Fazel, Mojtaba, Sarveazad, Arash, Mohamed Ali, Kosar, Yousefifard, Mahmoud, Hosseini, Mostafa
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury; HAVCR1 protein; Hepatitis A Virus Cellular Receptor 1; human; Renal Insufficiency; Review
• ISSN: 2645-4904
• DOI: 10.22037/aaem.v8i1.584

There is considerable controversy on the accuracy of Kidney Injury Molecule-1 (KIM-1) in prediction of acute kidney injury (AKI) in children. Therefore, the present study intends to provide a systematic review and meta-analysis of the value of this biomarker in predicting AKI in children. An extensive search was performed on the Medline, Embase, Scopus and Web of Science databases by the end of 2019. Cohort and case-control studies on children were included. Urinary KIM-1 levels were compared between AKI and non-AKI groups. Findings were reported as an overall standardized mean difference (SMD) with a 95% confidence interval (CI). Also, the overall area under the receiver operating characteristic (ROC) curve (AUC) of KIM-1 in predicting AKI in children was calculated. Data from 13 articles were included. Urinary KIM-1 levels in children with stage 1 AKI were higher than the non-AKI group only when assessed within the first 12 hours after admission (SMD = 0.95; 95% CI: 0.07 to 1.84; p = 0.034). However, urinary KIM-1 levels in children with stage 2-3 AKI were significantly higher than non-AKI children (p