Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds

Inflammation is the primary biological reaction to induce severe infection or injury in the immune system. Control of different inflammatory cytokines, such as nitric oxide (NO), interleukins (IL), tumor necrosis factor alpha-(TNF-α), noncytokine mediator, prostaglandin E2 (PGE2), mitogen activated...

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Bibliographic Details
Published in:Applied sciences 2021-11, Vol.11 (21), p.10092
Main Authors: Jayakumar, Thanasekaran, Sheu, Joen-Rong, Hsia, Chih-Wei, Bhavan, Periyakali Saravana, Chang, Chao-Chien
Format: Article
Language:English
Subjects:
anti-inflammatory effects
Cancer therapies
Cell division
Cisplatin
Cytokines
Drugs
Enzymes
Immune system
Immunosuppressive agents
Inflammation
inflammatory cytokines
Inflammatory diseases
Interleukins
Investigations
Kinases
Liver
MAPKs
Metal complexes
Metallography
Molecular modelling
NF-κB
NF-κB protein
Nitric oxide
Oxidative stress
Phosphorylation
Platinum
Prostaglandin E2
Protein kinase
ROS
Ruthenium
Ruthenium compounds
Transcription factors
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:Inflammation is the primary biological reaction to induce severe infection or injury in the immune system. Control of different inflammatory cytokines, such as nitric oxide (NO), interleukins (IL), tumor necrosis factor alpha-(TNF-α), noncytokine mediator, prostaglandin E2 (PGE2), mitogen activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB), facilitates anti-inflammatory effect of different substances. Coordination metal complexes have been applied as metallo-drugs. Several metal complexes have found to possess potent biological activities, especially anticancer, cardioprotective, chondroprotective and anti-parasitosis activities. Among the metallo drugs, ruthenium-based (Ru) complexes have paid much attention in clinical applications. Despite the kinetic nature of Ru complexes is similar to platinum in terms of cell division events, their toxic effect is lower than that of cisplatin. This paper reviews the anti-inflammatory effect of novel synthetic Ru complexes with potential molecular mechanisms that are actively involved.
ISSN:2076-3417
2076-3417
DOI:10.3390/app112110092