A rare case of tumefactive demyelination of brain: A case report and literature review

This case report highlights the diagnostic challenges encountered in a 30‐year‐old female presenting with fever followed by Wernicke's aphasia without right‐sided weakness, ultimately diagnosed as tumefactive demyelination (TD). TD is a rare neurological condition often misidentified as brain t...

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Bibliographic Details
Published in:Clinical case reports 2023-12, Vol.11 (12), p.e8369-n/a
Main Authors: Inban, Pugazhendi, Akuma, Ogbonnaya, Elavia, Zenia, Akuma, Chinaza Mercy, Singh, Mansi, Kachhadia, Meet Popatbhai, Musiime, Agaba Barnett James
Format: Article
Language:English
Subjects:
Abscesses
Aphasia
Blood
Brain cancer
Case Report
Case reports
cerebral spinal fluid (CSF)
Disease
Encephalomyelitis
Females
Fever
Inflammation
Magnetic resonance imaging
magnetic resonance imaging (MRI)
magnetic resonance spectroscopy (MRS)
Metabolites
Multiple sclerosis
Proteins
Respiratory Medicine
Sarcoidosis
Speech therapy
tumefactive demyelination (TD)
Tumors
Wernicke's aphasia
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Description
Summary:This case report highlights the diagnostic challenges encountered in a 30‐year‐old female presenting with fever followed by Wernicke's aphasia without right‐sided weakness, ultimately diagnosed as tumefactive demyelination (TD). TD is a rare neurological condition often misidentified as brain tumors or inflammatory disorders. The case emphasizes the importance of precise differentiation through advanced magnetic resonance imaging, showing restricted diffusion at lesion edges and the absence of gadolinium enhancement. Accurate diagnosis is crucial for tailored treatment and prognostic assessment. This case contributes to our understanding of TD and underscores the need for continued research and collaboration in the field of rare neurological disorders.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.8369