U-shaped association between low-density lipid cholesterol and diabetes mellitus in patients with hypertension

The magnitude and direction of association of low-density lipid cholesterol (LDL-C) with diabetes mellitus (DM) might differ by hypertensive status, but there is limited epidemiological evidence in China. We examined the association between LDL-C levels and DM in 9892 participants with hypertension...

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Bibliographic Details
Published in:Lipids in health and disease 2019-08, Vol.18 (1), p.163-163, Article 163
Main Authors: Liu, Lin, Shen, Geng, Huang, Jia-Yi, Yu, Yu-Ling, Chen, Chao-Lei, Huang, Yu-Qing, Feng, Ying-Qing
Format: Article
Language:English
Subjects:
Aged
Antilipemic agents
Asian Continental Ancestry Group
Cholesterol
Cholesterol tests
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Complications and side effects
Cross-Sectional Studies
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - diagnosis
Diabetes Mellitus - ethnology
Diabetes Mellitus - physiopathology
Epidemiology
Ezetimibe
Female
Humans
Hypertension
Hypertension - blood
Hypertension - diagnosis
Hypertension - ethnology
Hypertension - physiopathology
Low density lipoproteins
Low-density lipid cholesterol
Male
Middle Aged
Physiological aspects
Regression Analysis
Risk factors
Triglycerides - blood
Type 2 diabetes
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Summary:The magnitude and direction of association of low-density lipid cholesterol (LDL-C) with diabetes mellitus (DM) might differ by hypertensive status, but there is limited epidemiological evidence in China. We examined the association between LDL-C levels and DM in 9892 participants with hypertension using logistic regression. Participants were stratified into three groups according to LDL-C levels (desirable, borderline high or high), then further divided into quartiles. Restricted cubic spline regression models, subgroup analysis and interaction tests were also conducted to evaluate the shape of association. After adjusting for covariates, lower LDL-C had a significant and inverse association with the likelihood of DM in all participants (OR: 0.944, 95% CI = 0.893, 0.998). In participants with desirable LDL-C concentrations ( 4.1 mmol/L), LDL-C increased the DM likelihood (OR = 1.536, 95% CI = 1.126, 2.096 per 1 mmol/L increase). Restricted cubic spline regression also found a U-shaped association between LDL-C levels and DM prevalence. There was a U-shaped association between LDL-C levels and DM in Chinese patients with hypertension.
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-019-1105-5